CT导向下^(125)I粒子植入治疗肾上腺恶性肿瘤  

CT-guided radioactive seed ^(125)I implantation for the treatment of malignant adrenal neoplasms

作　　者：葛永斌[1] 范卫君[2] 张亮[2] 赵明[2] 

机构地区：[1]广州医学院附属肿瘤医院核医学科,510095 [2]中山大学肿瘤防治中心介入科

出　　处：《介入放射学杂志》2011年第4期307-310,共4页Journal of Interventional Radiology

摘　　要：目的探讨CT导向下125I粒子植入治疗肾上腺恶性肿瘤的疗效。方法回顾性分析行CT导向下125I粒子植入治疗的9例肾上腺恶性肿瘤患者(9个病灶)。采用治疗计划系统(TPS)模拟布源。在CT导向下将125I放射性粒子置入肾上腺肿瘤内。单个粒子的放射性活度为29.6 MBq,粒子相隔1.0～1.5 cm平面播植。治疗后1～15个月,复查增强CT扫描进行影像学疗效评价。结果 9例患者125I粒子植入治疗后肿瘤获得不同程度缓解,影像评价:完全缓解5例,部分缓解3例,无变化1例。治疗操作的主要并发症为少量出血(1例)。结论 CT导向下125I粒子植入治疗肾上腺恶性肿瘤近期疗效确切,是一种安全、有效的微创介入治疗方法。Objective To evaluate CT-guided radioactive seed 125I implantation in treating malignant adrenal neoplasms.Methods CT-guided radioactive seed 125I implantation was performed in 9 cases of malignant adrenal neoplasms with a total of 9 lesions.The clinical data were retrospectively analyzed.Treatment plan system was used to design the distribution of 125I seeds needed for teeatment.Under CT guidance,the 125I seeds of 29.6 MBq were implanted into the malignant adrenal neoplasms with an interval distance of 1.0-1.5 cm.A follow-up of 1-15 months was conducted.The postoperative efficacy was evaluated with enhanced CT scanning.Results After the treatment,complete remission（CR） was obtained in 5 patients,partial remission（PR） in 3 patients and no change（NC） in 1 patient,with an overall effective rate of 88.9%.The main complication was slight bleeding（n = 1）.Conclusion For the treatment of malignant adrenal neoplasms,CT-guided radioactive seed 125I implantation carries reliable short-term effectiveness,therefore,it is a safe,effective and minimally-invasive therapy.

关 键 词：肾上腺恶性肿瘤 CT导向 125I粒子植入治疗 

分 类 号：R736.6[医药卫生—肿瘤]