COX-2和bFGF在宫颈癌中的表达及其临床意义  

Expression of COX-2 and bFGF in Cervical Carcinoma and Its Clinical Significance

作　　者：罗春芳 王晖 洪慧莉 芦玉兰[3] 刘铭球[4] 

机构地区：[1]武汉市第三医院妇产科,武汉市430060 [2]武汉市第三医院病理科,武汉市430060 [3]武汉大学中南医院妇瘤科 [4]武汉大学医学院病理与病理生理学系

出　　处：《中国肿瘤临床》2011年第7期386-390,共5页Chinese Journal of Clinical Oncology

基　　金：武汉市卫生局科研项目基金资助(编号:2007-43)~~

摘　　要：目的:研究环氧合酶-2(COX-2)和碱性成纤维细胞生长因子(bFGF)在宫颈癌组织中的表达相关性及其临床意义。方法:采用组织芯片和免疫组化技术检测143例宫颈浸润癌(ICC)、20例癌旁正常宫颈上皮(NCE)中COX-2和bFGF的表达,统计分析COX-2、bFGF表达与病理分级、临床分期和淋巴结转移等临床病理因素的关系。结果:COX-2在ICC和NCE中的阳性表达率分别为87.4%(125/143)和40.0%(8/20),P<0.001 bFGF在ICC和NCE中的阳性表达率分别为88.8%(127/143)和25.0%(5/20),P<0.001。COX-2的表达与临床分期(r=0.222,P=0.008)、病理分级(r=0.354,P<0.001)和间质浸润深度(r=0.243,P=0.003)呈正相关。bFGF表达分别与淋巴结转移(r=0.239,P=0.004)和病理分级(t=0.369,P<0.001)呈正相关。COX-2和bFGF在宫颈癌组织中的表达强度呈正相关(r=0.234,P=0.005),二者表达一致的比例高达79.7%(114/143)。随着宫颈癌恶性度增高,COX-2和bFGF的表达呈上升趋势。结论:COX-2和bFGF的异常表达与宫颈癌的分化、侵袭和进展有关。联合检测COX-2和bFGF有助于判断宫颈癌的生物学行为和评估患者预后。Objective： To investigate the expression of cyclooxygenase-2 （ COX-2 ） and basic fibroblast growth tactor（ bFGF ） in cervical carcinoma and its clinical significance. Methods： Tissue microarray technique and immunohistochemistry SP method were used to detect the expression of COX-2 and bFGF in 143 tissue samples of invasive carcinoma of the cervix （ ICC ） and 20 tissue samples of paraneoplastic normal cervical epithelium （ NCE ）. The relationship of COX-2 and bFGF expression in ICC with the clinicopathologie factors including histopathological grading, nodal metastasis, stroma involvement, FIGO staging and histological type was analyzed. Results： The positive expression of COX-2 was significantly higher in ICC than in NCE [ 87.4% （ 125/143 ） vs. 40.0% （ 8/20 ）, P = 0.00 ]. The positive expression of bFGF was significantly higher in ICC than in NCE [ 88.8% （127/143） vs. 25.0% （5/20）, P = 0.00 ]. The expression of COX-2 was positively correlated with the FIGO staging, histopathological grading and stromal invasion （ r = 0.222, P = 0.008; r= 0.354, P= 0.00, and r = 0.243, P= 0.003, respectively ）. The expression of bFGF was positively correlated with lymph node metastasis and histopathologic grading （ r = 0.239, P = 0.004 and r = 0.369, P = 0.00, respectively ）. The expression of bF-GF was positively correlated with the expression of COX-2 in ICC （ r- 0.234, P = 0.005 ）. The ratio of the consistency between the expression of the two proteins was up to 79.7% （ 114/143 ）. With the increase of the malignant degree of cervical carcinoma, the expression of COX-2 and bFGF showed a rising tendency. Conclusion： The over-expression of COX-2 and bFGF is closely correlated with the invasion, progression and differentiation of cervical carcinoma. Joint detection of COX-2 and bFGF expression can help further understand the biological behavior of cervical carcinoma and predict its prognosis.

关 键 词：宫颈癌 环氧合酶-2 碱性成纤维细胞生长因子 组织芯片 相关性 

分 类 号：R737.33[医药卫生—肿瘤]