静止期牙周炎正畸牙周组织中胰岛素样生长因子-Ⅰ表达的实验研究  

Experimental Study of Insulin-like Growth Factor-Ⅰ Expression in Orthodontic Tooth Movement with Stable Periodontitis

作　　者：杨东红[1] 郑嵘[1] 曹作宏[2] 吴立鹏[1] 

机构地区：[1]佳木斯大学口腔医学院口腔正畸科,黑龙江佳木斯154002 [2]哈尔滨工程大学医院口腔科

出　　处：《口腔医学研究》2011年第4期292-295,共4页Journal of Oral Science Research

基　　金：黑龙江省自然科学基金项目(编号:D2007-87)

摘　　要：目的:对比分析IGF-Ⅰ在静止期牙周炎牙移动和正常牙移动牙周组织改建中的表达变化。方法:72只wistar大鼠随机平分为牙周炎牙移动及正常牙移动1、3、7、14、21d组及对照组,近中移动各组大鼠上颌第一磨牙,分别测量牙齿移动距离并进行IGF-Ⅰ免疫组化染色分析。结果:在既定时间内,牙周炎组大鼠牙移动距离大于正常组;牙周炎牙移动组的IGF-Ⅰ含量低于正常牙移动组,加力第1、7、14天差异有统计学意义。结论:IGF-Ⅰ作为局部调控因子参与了正畸牙周组织改建过程;在慢性炎症环境下,IGF-Ⅰ表达水平低于正常牙移动组。Objective：To compare and analyze the effect of IGF-Ⅰ on periodontal tissue remodeling during the tooth movement in rats with periodontitis and healthy periodontal tissue.Methods：Seventy-two Wistar rats were randomly divided into healthy and periodontitis tooth movement groups with 1th,3th,7th,14th,21th days and control group.With the maxillary first molar mesially moved,the rats were measured of distance of tooth movement and sections were detected by immunohistochemical stain.Results：In a given period of time,distance of tooth movement in periodontitis rats was longer than that in healthy group;IGF-Ⅰ was lower than that in healthy tooth movement group;the compressive side in the periodontal tissue 1th,7th,14th days groups showed significant difference from control.Conclusion：IGF-Ⅰ participated in the orthodontic periodontal tissue remodeling.Since the presence of chronic inflammatory environment,the expression level of IGF-Ⅰ in periodontitis toothmovement group decreased significantly.

关 键 词：牙周炎 牙移动 牙周组织改建 IGF-Ⅰ 

分 类 号：R783.5[医药卫生—口腔医学]