HA表达与鼻咽癌淋巴结转移的关系研究  

Study of Relation Between HA Expression and Lymph Node Metastasis in Nasopharyngeal Carcinoma

作　　者：孙德宇[1] 李霞[1] 王海东[2] 孔翔宇[1] 牟安娜[1] 

机构地区：[1]辽宁省肿瘤医院,辽宁沈阳110042 [2]铁法煤业集团总医院,辽宁调兵山112700

出　　处：《中国肿瘤》2011年第5期392-394,共3页China Cancer

摘　　要：[目的]研究HA表达与鼻咽癌淋巴结转移的关系,探索预测鼻咽癌淋巴结转移潜能的有效生物学指标,以指导鼻咽癌的治疗。[方法]RT-PCR方法检测50例鼻咽癌患者HAmRNA表达。[结果]RT-PCR结果显示,N(+)组表达高于N(-)组,相对含量分别为1.503±0.378和1.069±0.374,有统计学差异(P<0.05)。[结论]在鼻咽癌组织中有淋巴结转移组的HAmRNA相对含量显著高于无淋巴结转移组,HA的表达水平有可能成为预测鼻咽癌淋巴结转移的指标。[Purpose] To study the relationship of HA expression with nasopharyngeal carcinoma lymph node metastasis,and to explore molecular biological parameters for forecasting the potential of nasopharyngeal carcinoma lymph node metastasis,so as to guide the treatment for nasopharyngeal carcinoma.[Methods] The expression of HA mRNA was analyzed by reverse transcription-polymerase chain reaction（RT-PCR） in 50 patients with nasopharyngeal carcinoma.[Results] RT-PCR showed the expression of HA mRNA in lymph node metastasis group and no lymph node metastasis group was 1.503±0.378 and 1.069±0.374 respectively,with significant difference（P0.05）.[Conclusions] The expression of HA mRNA in lymph node metastasis group is significantly higher than that in no lymph node metastasis group in nasopharyngeal carcinoma tissue.The expression level of HA maybe become one of the parameters for forecasting lymph node metastasis in nasopharyngeal carcinoma.

关 键 词：显著高于无淋巴结转移组 HA的表达水平有可能成为预测鼻主题词:鼻咽癌 淋巴结转移 HA RT-PCR 

分 类 号：R739.62[医药卫生—肿瘤]