Preparation and osteoinduction of active micro-arc oxidation films on Ti-3Zr-2Sn-3Mo-25Nb alloy  

Ti-3Zr-2Sn-3Mo-25Nb合金表面活性微弧氧化膜的制备及其骨诱导性(英文)

作　　者：余森[1,2] 于振涛[1] GuiWANG 韩建业[1] 麻西群[1] Matthew S．DARGUSCH 

机构地区：[1]西北有色金属研究院,西安710016 [2]CAST Cooperative Research Centre,School of Mechanicaland Mining Engineering,The University of Queensland,Brisbane QLD4072,Australia

出　　处：《Transactions of Nonferrous Metals Society of China》2011年第3期573-580,共8页中国有色金属学报（英文版）

基　　金：Project (2005CB623904) supported by the National Basic Research Program of China;Project (30770586) supported by the National Natural Science Foundation of China;Project (31011120049) supported by the Australia-China special fund, International Science Linkages Program co-supported by the Department of Innovation, Industry, Science and Research of Australia, and the Ministry of Science and Technology and National Science Foundation of China;Project (2010ZDKG-96) supported by the major Subject of "13115" Programs of Shaan’xi Province, China

摘　　要：A layer of porous film containing Ca and P was prepared by the micro-arc oxidation method on the surface of a novel near β biomedical Ti-3Zr-2Sn-3Mo-25Nb alloy, and then NH2- active group was introduced to the films by activation treatment. The phase composition, surface micro-topography and elemental characteristics of the micro-arc oxidation films were investigated with XRD, SEM, EDS and XPS, and the osteoinduction of the micro-arc oxidation films was tested using the simulated body fluid immersion, the in-vitro osteoblast cultivation test and animal experiment. The results show that the oxide layer is a kind of porous ceramic intermixture and contains Ca and P. The films in the simulated body fluid can induce apatite formation, resulting in excellent bioactivity. The cell test discovers that osteoblasts can grow well on the surface of micro-arc oxidation films. And the Ti-3Zr-2Sn-3Mo-25Nb biomedical alloy coated with active porous calcium-phosphate films shows better osteoinduction in vivo.通过微弧氧化法在新型医用近β钛合金Ti-3Zr-2Sn-3Mo-25Nb表面制备一层含Ca、P多孔薄膜,再将其在胺基化溶液中活化处理以在薄膜表面引入NH-2。借助XRD、SEM和EDS研究该多孔复合薄膜的组成和表面形貌,并通过模拟体液浸泡实验、体外细胞培养实验和动物体内植入实验研究经上述表面改性处理后的Ti-3Zr-2Sn-3Mo-25Nb合金的骨诱导活性。结果表明:该薄膜主要由金红石型TiO2和锐钛矿型TiO2组成,是一种含有Ca、P的陶瓷混合物;薄膜在模拟体液中具有很好的生物活性,成骨细胞能够很好地在薄膜上分化、生长;表面覆膜处理的Ti-3Zr-2Sn-3Mo-25Nb合金的体内骨诱导活性优于未处理的Ti-3Zr-2Sn-3Mo-25Nb合金的。

关 键 词：β titanium alloy Ti-3Zr-2Sn-3Mo-25Nb alloy OSTEOINDUCTION micro-arc oxidation surface modification 

分 类 号：TG174.4[金属学及工艺—金属表面处理]