MECT对严重抑郁患者认知功能的影响  

Effect of medified electroconvulsive therapy on the cognition of patients with major depression disorder

作　　者：楼丹丹[1] 况利[1] 甘窈[1] 

机构地区：[1]重庆医科大学附属第一医院心理卫生中心,重庆400016

出　　处：《重庆医科大学学报》2011年第3期342-343,共2页Journal of Chongqing Medical University

基　　金：重庆市科委资助项目(编号:CSTC2007BB5318)

摘　　要：目的:评定无抽搐电休克治疗对严重抑郁患者认知功能产生的影响。为临床无抽搐电休克治疗提供理论依据。方法:符合中国精神障碍分类与诊断标准第3版的抑郁症标准,汉密尔顿抑郁量表(Hamilton depression scale,HAMD)17项总分≥24分的严重抑郁症患者进行了至少6次双侧电极无抽搐电休克治疗,分别于治疗前、第1次治疗后、第6-8次治疗后进行汉密尔顿抑郁量表(HAMD)及韦氏记忆量表(Wechsler memoryscale,WMS)评定。结果:无抽搐电休克治疗严重抑郁症后临床症状明显好转(P<0.01),但对记忆有一定的影响,这种影响于患者接受第6次至第8次治疗时逐渐恢复。结论:无抽搐电休克治疗对严重抑郁症患者临床症状有明显的改善,且对患者记忆的影响是可逆的。Objective： To estimate the influence of modified electroconvulsive therapy（MECT） on the cognition of patients with major depression.Methods： Patients metting CCMD 3 criteria for major depression,whose scores of HAMD 17-item were above 24,were treated with bilateral,brief pulse,square wave stimulus,dose titration MECT.Before and after the 1st and 6-8th course of treatment,Hamilton depression scale and Wechsler memory scale were tested.Results：There was significant amelioration of clinical symptoms after MECT（P 0.01）,but it had negative impact on memory,which would last till the 6-8th course of treatment.Conclusion： MECT may improve the symptoms of patients with severe depression and irreversibly influnce the memory.

关 键 词：无抽搐电抽搐治疗 严重抑郁症 认知 

分 类 号：R749[医药卫生—神经病学与精神病学]