非小细胞肺癌^(18)F-FDG PET-CT影像与Survivin  

Correlation between ^(18)F-FDG PET-CT signs with the expression of Survivin and clinicopathological factors in non-small cell lung cancer tissues

作　　者：林珊[1] 韩波[1] 于丽娟[2] 王瑞芝[3] 宁晓明[4] 

机构地区：[1]哈尔滨医科大学附属第一医院肿瘤科二病房,黑龙江哈尔滨150001 [2]哈尔滨医科大学附属肿瘤医院PET-CT中心,黑龙江哈尔滨150081 [3]哈尔滨医科大学附属肿瘤医院肿瘤放疗科,黑龙江哈尔滨150081 [4]哈尔滨医科大学附属肿瘤医院病理科,黑龙江哈尔滨150081

出　　处：《中华肿瘤防治杂志》2011年第3期196-199,共4页Chinese Journal of Cancer Prevention and Treatment

基　　金：黑龙江省教育厅课题资助项目(11551272);哈尔滨医科大学附属第一医院基金资助项目(2007108)

摘　　要：目的:探讨非小细胞肺癌氟-18-2-脱氧-D-葡萄糖(18F-FDG)正电子发射体层成像(PET-CT)的标准摄取值(SUV)与凋亡抑制基因Survivin表达间的关系。方法:选择行18F-FDG PET-CT扫描并经手术确诊的NSCLC患者33例,Survivin的检测,并结合临床病理特点进行统计学分析。结果:33例NSCLC病例PET-CT的SUVmax平均为10.5±5.4,SUVmax与病理类型(鳞癌和腺癌,r=0.432,P=0.012)、临床分型(中心型和周围型,r=0.379,P=0.029)及病灶大小(r=0.743,P=0.000)具有显著的相关性;Survivin表达的阳性率为84.8%(28/33),腺癌的阳性表达高于鳞癌,u=2.29,P=0.022;SUVmax与Survivin的表达无明显相关性,与年龄、性别、病理分级、TNM分期及淋巴结转移无明显相关性。结论:PET-CT的SUVmax与组织病理类型、临床分型及病灶大小有关,Survivin的表达与组织病理类型有关,SUVmax与Survivin表达无明显相关性。OBJECTIVE：The study focused on the correlation between PET-CT signs with the expression of Survivin（an inhibitor of apoptosis protein） and clinicopathological characteristics in non-small cell lung cancer（NSCLC）.METHODS： Thirty-three cases of non-small cell lung cancer confirmed by pathology were examined with 2-deoxy-18F-fluoro-D-glucose（18F-FDG） PET before operation.The expression of Survivin was evaluated by immunohistochemical assay in 33 NSCLC tumor samples.The maximum standarized uptake value（SUVmax）,Survivin and eight clinicopathological factors were analyzed respectively.RESULTS： The mean of SUVmax in 33 NSCLC was 10.5 ± 5.4.The correlation between SUVmax and histological type（r=0.432,P=0.012）,clinical type（r=0.379,P=0.029）,size of lesion（r=0.743,P=0.000） were significant in the entire group;the positive expression rate of Survivin was 84.8%（28/33）.It is higher in adenocarcinoma than that in squmous cell carcinoma（u=2.29,P=0.022）;SUVmax showed no relation to the expression of Survivin,age,gender,differentiation,TNM stage and lymph node metastasis.CONCLUSION： SUVmax is correlated with histopathological type,clinical type and size of lesion,the correlation between Survivin and histological type was significant,but SUVmax showed no relation to the expression of Survivin.

关 键 词：癌 非小细胞肺 正电子发射断层显像术 病理学 临床 

分 类 号：R734.2[医药卫生—肿瘤]