地西泮与丙戊酸钠治疗癫痫持续状态的疗效比较  

Comparison of effects of diazepam and sodium valproate on status epilepticus

作　　者：孙洲[1] 王磊[1] 龚瑜[2] 孙圣刚[1] 苏颖[1] 梁直厚[1] 

机构地区：[1]华中科技大学同济医学院附属协和医院神经内科,武汉430022 [2]湖北省新华医院内二科

出　　处：《临床急诊杂志》2011年第2期93-94,共2页Journal of Clinical Emergency

摘　　要：目的:回顾性比较丙戊酸钠注射液与地西泮治疗癫痫持续状态的疗效。方法:选择我院神经内科近两年来收治的成人癫痫持续状态患者35例。地西泮组16例入院后立即予地西泮10mg以2mg·min-1静脉缓慢注射,注射完毕后给予地西泮50mg加0.9%氯化钠注射液500ml静脉缓慢滴注维持,24h总量不超过120mg;丙戊酸钠组19例入院后立即予丙戊酸钠注射液400mg静脉注射,注射完毕后给予丙戊酸钠400mg加0.9%氯化钠注射液50ml静脉微泵缓慢注射维持,24h总量不超过20～30mg·kg-1。结果:两组抽搐控制率、抽搐控制时间、48h内复发率比较均差异无统计学意义。结论:丙戊酸钠注射液与地西泮在治疗癫痫持续状态疗效方面无明显差别。Objective：To explore the effects of diazepam and sodium valproate injection in treating status epilepticus（SE） . Method：Thirty five adult patients with status epilepticus were observed. In diazepam group（sixteen patients） ,diazepam was given by intravenous injection at 10 mg with 2 mg·min-1,then diazepam 50 mg plus 0.9% sodium chloride injection 500 ml was given continuously by intravenous drip,and the total quantity is no more than 120 mg in 24 h. In sodium valproate group（nineteen patients） ,sodium valproate injection 400 mg was administered by intravenous,then sodium valproate 400 mg injection plus 0.9% sodium chloride injection 50 ml was pumped by intravenous,and the total quantity was no more than 20～30 mg·kg-1 in 24 h. Result：There was no significant difference between diazepam group and sodium valproate group in treating status epilepticus on effective rate,control time and 48 h recurrence rate. Conclusion：The difference of effect between diazepam and sodium valproate in treating status epilepticus was no significant.

关 键 词：丙戊酸钠 地西泮 癫痫持续状态 

分 类 号：R742.1[医药卫生—神经病学与精神病学]