Study on Characteristics of Acellular Bovine Pericardium Crosslinked with Genipin  

作　　者：TIAN Cong WAN Rong-xin GU Han-qing LIU Xin 

机构地区：[1]Department of Biomedical Engineering, Tianjin Medical University, Tianjin 300070, China [2]Tianjin Institute of Urological Surgery, Tianjin 300211, China

出　　处：《Chinese Journal of Biomedical Engineering(English Edition)》2011年第1期10-18,共9页中国生物医学工程学报（英文版）

基　　金：National High-tech Research and Development Program(836 Prgoram) of China;grant number:2007AA02Z444;National BasicProgram of China (973 Program);grant number:2009CB930000

摘　　要：The study used a naturally occurring crosslinking reagent-genipin to chemically modify acellular bovine pericardium, prepare cardiac valve tissue engineering scaffold material,and evaluated genipin crosslinked acellular matrix of bovine pericardium by investigating the physical and chemical properties of the tissues, such as the surface properties, crosslinking characteristics, mechanical properties, resistance to enzymatic capacity in vitro, and hemolysis tests. The results showed that acellular bovine pericardium matrix erosslinked with genipin was strong hydrophilicity, high crosslinking index, and stable structure, which can maintain good mechanical properties. As a kind of scaffold material for valve tissue engineering, it has wide application prospect.The study used a naturally occurring crosslinking reagent-genipin to chemically modify acellular bovine pericardium, prepare cardiac valve tissue engineering scaffold material,and evaluated genipin crosslinked acellular matrix of bovine pericardium by investigating the physical and chemical properties of the tissues, such as the surface properties, crosslinking characteristics, mechanical properties, resistance to enzymatic capacity in vitro, and hemolysis tests. The results showed that acellular bovine pericardium matrix crosslinked with genipin was strong hydrophilicity, high crosslinking index, and stable structure, which can maintain good mechanical properties. As a kind of scaffold material for valve tissue engineering, it has wide application prospect.

关 键 词：acellular bovine pericardium GENIPIN GLUTARALDEHYDE crosslinking characteristics mechanical properties 

分 类 号：TQ316.64[化学工程—高聚物工业] Q249[生物学—细胞生物学]