GENIPIN

作品数：31被引量：94H指数：6
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相关作者：杨永安谷江杨永安王利君边瑞琦更多>>
相关机构：吉林大学贵阳医学院附属医院南京医科大学河北大学更多>>
相关期刊：《International Journal of Ophthalmology(English edition)》《Chinese Medical Journal》《World Journal of Diabetes》《现代食品科技》更多>>
相关基金：国家自然科学基金国家重点基础研究发展计划先进纺织材料与制备技术教育部重点实验室开放基金浙江省自然科学基金更多>>
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Potential prospects of Chinese medicine application in diabetic retinopathy
《World Journal of Diabetes》2024年第10期2010-2014,共5页Yi-Mai Zhou Yuan-Hao Cao Jing Guo Lu-Sha Cen 
Supported by National Natural Science Foundation of China,No.82104862;Scientific Research Project Foundation of Zhejiang Chinese Medical University,No.2023FSYYZZ01 and No.2023RCZXZK49.
Current treatment strategies for diabetic retinopathy(DR),an eye condition that can lead to blindness,have mainly focused on proliferative DR,including vitreous injection,retinal photocoagulation,and vitrectomy.Vitreo...
关键词：Diabetic retinopathy Traditional Chinese medicine GENIPIN Topical application Advanced glycation end products 
A temperature-regulated bioorthogonal reaction to target lysine:Hemiacetal pharmacophore in genipin irreversibly binds with UCP2,inhibiting mitochondrial thermogenesis
《Chinese Chemical Letters》2023年第10期191-196,共6页Fukui Shen Wen Yang Kaixue Zhang Yanting Jiao Jing Cui Yuanyuan Hou Gang Bai 
supported by the National Natural Science Foundation of China(No.81973449);the National Key Research and Development Program of China(Nos.2018YFC1704800 and 2018YFC1704805);。
Mitochondria are essential for eukaryotic life as powerhouses for energy metabolism. Excessive mitochondrial hyperthermia and reactive oxygen species(ROS) production have been associated with aging, cancer,neurodegene...
关键词：Bioorthogonal reaction Mitochondria GENIPIN UCP2 Irreversible binding 
Genipin relieves diabetic retinopathy by down-regulation of advanced glycation end products via the mitochondrial metabolism related signaling pathway被引量：4
《World Journal of Diabetes》2023年第9期1349-1368,共20页Ke-Xin Sun Yan-Yi Chen Zhen Li Shi-Jie Zheng Wen-Juan Wan Yan Ji Ke Hu 
the National Natural Science Foundation of China,No.81870650,No.81570832,and No.81900885;Science and Technology Program Chongqing,No.2018GDRC008 and No.XKTS049。
BACKGROUND Glycation is an important step in aging and oxidative stress,which can lead to endothelial dysfunction and cause severe damage to the eyes or kidneys of diabetics.Inhibition of the formation of advanced gly...
关键词：GENIPIN Human retinal microvascular endothelial cells ANGIOGENESIS VASCULARIZATION Secretogranin III Diabetic retinopathy 
Anti-Seizure and Neuronal Protective Effects of Irisin in Kainic Acid-Induced Chronic Epilepsy Model with Spontaneous Seizures被引量：2
《Neuroscience Bulletin》2022年第11期1347-1364,共18页Jie Yu Yao Cheng Yaru Cui Yujie Zhai Wenshen Zhang Mengdi Zhang Wenyu Xin Jia Liang Xiaohong Pan Qiaoyun Wang Hongliu Sun 
the National Natural Science Foundation of China(81573412 and 81803546);Key Research and Development Plan of Shandong Province(2018GSF121004);Yantai Science and Technology Development Plan(2019xdhz098).
An increased level of reactive oxygen species is a key factor in neuronal apoptosis and epileptic seizures.Irisin reportedly attenuates the apoptosis and injury induced by oxidative stress.Therefore,we evaluated the e...
关键词：EPILEPSY SEIZURE Irisin GENIPIN Neuronal injury 
The effect of nano-calcium carbonate onβ-glucosidase immobilized by alginate and chitosan
《Green Synthesis and Catalysis》2022年第3期265-271,共7页Mariam Iqbal Yuefeng Deng Qiaoyue Chen Chengli Yang Yihui Zhu Ziqian Chen Jianjun Wang Kaishun Hu Guanya He Dali Li 
Nanotechnology has become the most promising domain to boost the efficiency of enzymes.Enzymes are vital as a green catalyst in many industries,food,pharmaceutical and biomedical,etc.The immobilization process of the ...
关键词：IMMOBILIZATION Nano-CaCO_(3) Sodium alginate CHITOSAN GENIPIN 
Genipin improves lipid metabolism and sperm parameters in obese mice via regulation of miR-132 expression被引量：4
《Acta Biochimica et Biophysica Sinica》2022年第9期1278-1288,共11页Li Wangi Ge Chen Shuyao Wu YihuaXul Chenxi Guo Manman Wang Tingming Liang Zhigang Guo Hong-Jie Di Zhigang Hu 
the grants from the National Natural Science Foundation of China(No.32171407);the Development Project of Jiangsu Province TCM Science and Technology(No.YB2020024);the Priority Academic Program Development of Jiangsu Higher Education Institutions.
Obesity has now surpassed malnutrition and infectious diseases as the most significant contributor to health problems worldwide.In particular,obesity is associated with several metabolic disorders,including hyperlipid...
关键词：metabolic disorder sperm function miR-132 OBESITY GENIPIN 
Hepatic CYP3A4,SULT2A1,and UGT1A1 synergistically mediate metabolic detoxification of genipin被引量：2
《Journal of Chinese Pharmaceutical Sciences》2022年第8期608-621,共14页Fan Zhang Xiaohui Wang Abdulaziz Ahmed ASaad Lili Xi Xiaohua Ma Axi Shi Yuhui Wei 
National Natural Science Foundation of China(Grant No.82174067,81960646 and 82004080)。
In the present study,we aimed to ascertain the metabolic detoxification routes of genipin via CYP3A4,SULT2 A1,and UGT1 A1 in Hepa RG cells.It was found that the hepatic CYP3A4,SULT2 A1,and UGT1 A1 synergistically medi...
关键词：GENIPIN Metabolic detoxification CYP3A4 SULT2A1 UGT1A1 Gardenia jasminoides Ellis 
Modelling the mechanism and kinetics of ascorbic acid diffusion in genipin-crosslinked gelatin and chitosan networks at distinct pH
《Food Bioscience》2022年第2期684-694,共11页Felicity A.Whitehead Stefan Kasapis 
This research is supported by an Australian Government Research Training Program(RTP)Scholarship to Felicity Whitehead.
Crosslinked biopolymers were prepared for controlled release to investigate the diffusion of ascorbic acid from swelling high-solid networks in neutral and acidic pH conditions.Polymer swelling was measured at pH 2.8 ...
关键词：GELATIN CHITOSAN Genipin crosslinking Ascorbic acid Diffusion kinetics 
Genipin and geniposide from Gardenia jasminoides:An overview of their anti-cancer and other pharmacological properties
《Journal of Chinese Pharmaceutical Sciences》2022年第1期1-12,共12页Eric Wei Chiang Chan Siu Kuin Wong Hung Tuck Chan 
Genipin and geniposide are iridoids from the fruits of Gardenia jasminoides.Both compounds have a methyl acetate(-COOCH_(3))group at C4 and a hydroxyl(-OH)group at C10.As an iridoid glucoside with a glucose moiety at ...
关键词：IRIDOID Iridoid glucoside ANTI-CANCER CYTOTOXICITY 
Development of genipin crosslinked gelatin matrices on surface interaction: Enhancing the biocompatibility by attenuating sterile inflammation
《Chinese Journal of Chemical Engineering》2021年第10期205-215,共11页Qiang-Song Wang Gui-Fang Wang Hai-Yun Zhang Fa-Quan Zhao Yuan-Lu Cui 
supported by the National Natural Science Foundation of China(81741119);Fundamental Research Funds for the Central Universities,China(3332020059)。
The inflammation can be stimulated by the surgical implantation and biomaterial presence through the foreign body via bio-interface.Macrophages play a key role in the interaction of host tissue to implant surfaces.In ...
关键词：GENIPIN Gelatin matrices ANTI-INFLAMMATION BIOCOMPATIBILITY NF-κB 
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