Genipin and geniposide from Gardenia jasminoides:An overview of their anti-cancer and other pharmacological properties  

作　　者：Eric Wei Chiang Chan Siu Kuin Wong Hung Tuck Chan 

机构地区：[1]Faculty of Applied Sciences,UCSI University,56000 Cheras,Kuala Lumpur,Malaysia [2]School of Foundation Studies,Xiamen University Malaysia,Bandar Sunsuria,43900 Sepang,Selangor,Malaysia [3]Secretariat of International Society for Mangrove Ecosystems(ISME),Faculty of Agriculture,University of the Ryukyus,Okinawa 903-0129,Japan

出　　处：《Journal of Chinese Pharmaceutical Sciences》2022年第1期1-12,共12页中国药学（英文版）

摘　　要：Genipin and geniposide are iridoids from the fruits of Gardenia jasminoides.Both compounds have a methyl acetate(-COOCH_(3))group at C4 and a hydroxyl(-OH)group at C10.As an iridoid glucoside with a glucose moiety at C1,geniposide is also known as genipin-1-O-β-D-glucoside.Without the glucose moiety,genipin is an iridoid and the aglycone of geniposide.The-OH group at C1 of genipin is responsible for its cytotoxic effects.Geniposide without the-OH group at C1 lacks the cytotoxic effects.There are more publications on the anti-cancer properties of genipin than geniposide.Studies have reported the potentiation of genipin when used in combination with anti-cancer drugs.The anti-cancer properties of geniposide have been investigated using human intestinal microflora that hydrolyzes geniposide to genipin.Both genipin and geniposide exert antiproliferative and apoptotic activities via different molecular targets and pathways.Other pharmacological properties of genipin and geniposide include antidepressant,antidiabetic,anti-inflammatory,anti-obesity,anti-thrombotic,hepatoprotective,and neuroprotective activities.Future research on genipin and geniposide is suggested.

关 键 词：IRIDOID Iridoid glucoside ANTI-CANCER CYTOTOXICITY 

分 类 号：R284[医药卫生—中药学]