IRIDOID

作品数：20被引量：47H指数：4
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相关领域：医药卫生理学更多>>
相关作者：姚海燕库宝善郑宜王英锋更多>>
相关机构：南京大学北京大学首都师范大学中国科学院大学更多>>
相关期刊：《Chinese Herbal Medicines》《Chinese Journal of Natural Medicines》《Journal of Chinese Pharmaceutical Sciences》《Molecular Plant》更多>>
相关基金：国家自然科学基金泰国研究基金北京市自然科学基金国家重点基础研究发展计划更多>>
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Genipin and geniposide from Gardenia jasminoides:An overview of their anti-cancer and other pharmacological properties
《Journal of Chinese Pharmaceutical Sciences》2022年第1期1-12,共12页Eric Wei Chiang Chan Siu Kuin Wong Hung Tuck Chan 
Genipin and geniposide are iridoids from the fruits of Gardenia jasminoides.Both compounds have a methyl acetate(-COOCH_(3))group at C4 and a hydroxyl(-OH)group at C10.As an iridoid glucoside with a glucose moiety at ...
关键词：IRIDOID Iridoid glucoside ANTI-CANCER CYTOTOXICITY 
<i>Morinda citrifolia</i>(Noni) Fruit Juice Inhibits SARS-CoV-2 Spike Protein Binding of Angiotensin-Converting Enzyme 2 (ACE2)
《Journal of Biosciences and Medicines》2021年第11期42-51,共10页Brett J. West Shixin Deng 
COVID-19 is a global pandemic that has claimed millions of lives. This disease is caused by a coronavirus, SARS-CoV-2, which requires the binding of its spike protein to angiotensin-converting enzyme 2 (ACE2) for infe...
关键词：CORONAVIRUS COVID-19 SARS-CoV-2 Spike Protein Morinda citrifolia NONI IRIDOID 
Discovery of New Iridoids as Farnesoid X Receptor Agonists from Morinda officinalis: Agonistic Potentials and Molecular Stimulation被引量：1
《Chinese Journal of Chemistry》2021年第5期1288-1296,共9页Zhi-Lin Luan Fei Qiao Wen-Yu Zhao Wen-Hua Ming Zhen-Long Yu Jie Liu Sheng-Yun Dai Shuang-Hui Jiang Chao-Jie Lian Cheng-Peng Sun Bao-Jing Zhang Jian Zheng Shuang-Cheng Ma Xiao-Chi Ma 
the National Natural Science Foundation of China(No.81703679);the Liaoning Provincial Key Research and Development Program(No.2019JH2/10300022);the Natural Science Foundation of Liaoning Province(No.2020-MS-256);the Dalian Young Star of Science and Tech nology(Nos.2019RQ123 and 2019RQ116).
The investigation of Morinda officinalis led to the isolation of twelve compounds(1-12),including three new iridoid glycosides morindallns A-C(1-3)and nine known compounds(4-12).Their structural identifications were c...
关键词：Morinda officinalis IRIDOID Farnesoid X receptor Agonistic effect 
Effects of total iridoid glycosides of Picrorhiza scrophulariiflora against non-alcoholic steatohepatitis rats induced by high-fat and high-sugar diet through regulation of lipid metabolism被引量：4
《Chinese Herbal Medicines》2020年第1期67-72,共6页Xu Xu Wei-ting Wang Zhuan-you Zhao Wen-gong Xi Bing Yu Chun-hua Hao Xin Li Wen-bin Hou Li-da Tang 
supported by National Science and Technology Major Project(No.2014ZX09101021-001);Science and Technology Planing Program of Tianjin Province(No.15ZXXYSY00070).
Objective:To investigate the therapeutic effect of total iridoid glycosides of Picrorhiza scrophulariiflora(TIGP)on non-alcoholic steatohepatitis(NASH).Methods:SD rats were fed with high-fat and high-sugar diet for 8 ...
关键词：HOMA-IR leptin non-alcoholic STEATOHEPATITIS TNF-α total IRIDOID GLYCOSIDES of Picrorhiza scrophulariiflora 
Cornel iridoid glycoside induces autophagy to protect against tau oligomer neurotoxicity induced by activation of glycogen synthase kinase-3β被引量：4
《中国药理学与毒理学杂志》2019年第6期456-456,共1页YANG Cui-cui LI Xue-lian ZHANG Li LI Ya-li LI Lin ZHANG Lan 
Tau oligomers are the etiologic molecules of Alzheimer disease(AD), and correlate strongly with neuronal loss and exhibit neurotoxicity. Recent evidence indicates that small tau oligomers are the most relevant toxic a...
关键词：cornel IRIDOID GLYCOSIDE AUTOPHAGY TAU OLIGOMER GLYCOGEN synthase kinase-3β 
Cornel iridoid glycoside protects against white matter lesions induced by cerebral ischemia via activation of neuregulin-1 pathway in rats
《中国药理学与毒理学杂志》2019年第6期451-451,共1页WANG Ming-yang HUA Xue-si NIU Hong-mei SUN Zheng-yu ZHANG Li LI Ya-li ZHANG Lan LI Lin 
Ischemic stroke often elicits profound white matter lesions, which results in poor neurological outcomes and impairing the recovery in post-stroke. However, few studies have focused on white matter lesions caused by c...
关键词：cornel IRIDOID GLYCOSIDE white matter lesions cerebral ischemia BRAIN-DERIVED NEUROTROPHIC factor NEUREGULIN-1 PATHWAY 
Phylogenomic Mining of the Mints Reveals Multiple Mechanisms Contributing to the Evolution of Chemical Diversity in Lamiaceae被引量：11
《Molecular Plant》2018年第8期1084-1096,共13页Mint Evolutionary Genomics Consortium 
Funds for this study were provided by a grant to C.R.B., N.D., S.E.O., D.S., and P.S. from the National Science Foundation Plant Genome Research Program （IOS-1444499） and from Hatch Funds （MICL02431） to C.R.B.
The evolution of chemical complexity has been a major driver of plant diversification, with novel compounds serving as key innovations. The species-rich mint family （Lamiaceae） produces an enormous variety of compou...
关键词：chemodiversity EVOLUTION TERPENE IRIDOID 
Pharmacokinetic Analysis of Four Bioactive Iridoid and Secoiridoid Glycoside Components of Radix Gentianae Macrophyllae and Their Synergistic Excretion by HPLC-DAD Combined with Second-Order Calibration
《Natural Products and Bioprospecting》2017年第6期445-459,共15页Tian-Ming Yang Yang-Xi Liu Hai-Yan Fu Wei Lan Han-Bo Su He-Bin Tang Qiao-Bo Yin He-Dong Li Li-Ping Wang Hai-Long Wu 
support from the National Natural Science Foundation of China(Grants Nos.21776321,21576297,21205145,21575039);Key Projects of Technological Innovation of Hubei Province(2016ACA138);The Open Research Program(Grant Nos.2015ZD001,2015ZD002 and 2015ZY006)。
An HPLC-DAD method combined with second-order calibration based on the alternating trilinear decomposition(ATLD)algorithm with the aid of region selection was developed to simultaneously and quantitatively characteriz...
关键词：Radix Gentianae Macrophyllae HPLC-DAD Second-order calibration Pharmacokinetic analysis 
Cornel iridoid glycoside inhibits tau hyper-phosphorylation by enhancing PP2A activity
《中国药理学与毒理学杂志》2015年第S1期46-46,共1页Cui-cuiYANG Xue-xianKUAI Ya-liLI LiZHANG LinLI LanZHANG 
The project supported by National Natural Science Foundation of China(81274120,81273498);the Beijing Natural Science Foundation(7132110);the Beijing Science and Technology Program(Z131102002813066);the Capital Health Development Scientific Grant(2011-1001-05)
OBJECTIVE The aim of the present study was to investigate the effect of cornel iridoid glycoside(CIG)on tau hyperphosphorylation induced by wortmannin(WT)and GF-109203X(GFX)and the underlying mechanisms.METHODS Human ...
关键词：cornel IRIDOID GLYCOSIDE Alzheimer′s disease TAU h 
Gastroprotective effect of the iridoid fraction from Barleria prionitis leaves on experimentally-induced gastric ulceration被引量：2
《Chinese Journal of Natural Medicines》2014年第10期738-744,共7页Sunil K.Jaiswal Mukesh K.Dubey Sanjib Das Ch.V.Rao 
AIM: To study the gastroprotective effect and in vivo antioxidant potential of a standardized iridoid fraction from B. prionitis leaves(BPE) against different gastric ulcer models in rats. METHOD: The standardized iri...
关键词：Barleria prionitis IRIDOID HPTLC Anti-ulcer activity Antioxidant enzymes 
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