GLYCOSIDE

作品数：199被引量：567H指数：11
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相关领域：医药卫生理学更多>>
相关作者：龚建光邓旭明许超谢光洪周昌芳更多>>
相关机构：浙江省人民医院北京大学吉林大学北京微量化学研究所更多>>
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Corrigendum: Neuroprotection by cattle encephalon glycoside and ignotin beyond the time window of thrombolysis in ischemic stroke
《Neural Regeneration Research》2025年第12期3429-3429,共1页
The biosynthesis of asiaticoside and madecassoside reveals tandem duplication-directed evolution of glycoside glycosyltransferases in the Apiales被引量：1
《Plant Communications》2024年第10期166-179,共14页Xiaoyang Han Jingyi Zhao Hong Zhou Xuan Zhou Zixin Deng Zhenhua Liu Yi Yu 
supported by the Guangxi Science and Technology Base and Talent Special Project(AD23026030);the Guiding Funds of Central Government for Supporting the Development of the Local Science and Technology(ZY23055032);the National Natural Science Foundation of China(22277095)to Y.Y;Research in the Z.L.group is supported by a Key Project at the Central Government level:the Ability Establishment of Sustainable Use for Valuable Chinese Medicine Resources(2060302);the National Technologies Key R&D Program of China(2022YFC2602000)。
Certain plant species within the Apiales order accumulate triterpenoid saponins that feature a distinctive glucose-glucose-rhamnose(G-G-R)sugar chain attached at the C-28 position of the pentacyclic triterpene skeleto...
关键词：triterpenoid saponin glycoside glycosyltransferases BIOSYNTHESIS ASIATICOSIDE MADECASSOSIDE Centella asiatica 
Constituents from leaves of Macaranga hemsleyana
《Chinese Herbal Medicines》2024年第3期481-486,共6页Joseph Sakah Kaunda Jia Liu Yaojun Xu Yuansi Chen Chenfang Yue Xingjie Zhang Ruihan Zhang Muhammad Amin Weilie Xiao Hongliang Li Xiaoli Li 
supported by the National Natural Science Foundation of China(No.81860615,82260682);Project of Yunnan Characteristic Plant Screening and R&D Service CXO Platform(No.2022YKZY001).
Objective:To study constituents of the leaves of Macaranga hemsleyana,and evaluate their inhibitory effects against NOD-like receptor thermal protein domain associated protein 3(NLRP3)inflammasome activation,and antip...
关键词：antiproliferative activity chemotaxonomic significance FLAVONOIDS GLYCOSIDE Macaranga hemsleyana Pax et Hoffm NLRP3 inflammasome 
Effect of moxibustion on expression profile of miRNAs in Tripterygium glycoside-induced decreased ovarian reserve
《Journal of Traditional Chinese Medicine》2024年第4期745-752,共8页SHEN Jie YIN Yaoli LI Hongxiao LU Ge ZHU Yaoyao QIN Yantong JIN Xun CHENG Jie SHEN Meihong 
the National Natural Science Foundation of China:Based on Phosphatidylinositol-3-kinase/Protein kinase B Signaling Pathway Study microRNAs Regulating Mechanism of Moxibustion Improve Ovarian Function(No.81804179);to Explore the miRNA Mechanism of Acupuncture and Moxibustion Against Oxygen Stress in Improving Ovarian Function based on Nuclear Factor Erythropoietin-2-related Factor 2/AU-rich Element Pathway(No.81774408);to Explore the Effect and Molecular Mechanism of Moxibustion on Granulosa Cells in Premature Ovarian Failure based on"Autophagy-apoptosis Cross-talk"(No.81973957)。
OBJECTIVE:To explore the possible regulatory mechanism of microRNA(miRNA)in moxibustion treatment for decreased ovarian reserve(DOR).METHODS:The DOR model was constructed by intragastrical Tripterygium glycoside suspe...
关键词：ovarian reserve MOXIBUSTION MICRORNAS mechanics 
Exercise-induced modulation of miR-149-5p and MMP9 in LPS-triggered diabetic myoblast ER stress: licorice glycoside E as a potential therapeutic target被引量：1
《Traditional Medicine Research》2024年第8期23-34,共12页Yi Du Hong Liu 
Background:This study explores the relationship between endoplasmic reticulum(ER)stress and diabetes,particularly focusing on the impact of physical exercise on ER stress mechanisms and identifying potential therapeut...
关键词：ER stress diabetes physical exercise gene expression microRNA-149-5p MMP9 licorice glycoside E traditional physical therapy genomics insights 
A novel marine-derived anti-acute kidney injury agent targeting peroxiredoxin 1 and its nanodelivery strategy based on ADME optimization
《Acta Pharmaceutica Sinica B》2024年第7期3232-3250,共19页Ping Yu Tanwei Gu Yueyang Rao Weimin Liang Xi Zhang Huanguo Jiang Jindi Lu Jianglian She Jianmin Guo Wei Yang Yonghong Liu Yingfeng Tu Lan Tang Xuefeng Zhou 
supported by the Guangdong Local Innovation Team Program(2019BT02Y262,China);National Natural Science Foundation of China(U20A20101,82274002,22175083);Key-Area Research and Development Program of Guangdong Province(2023B1111050008,China);National Key Research and Development Program of China(2022YFA1206900,2023YFA0914200);Science and Technology Innovation Project of Guangdong Medical Products Administration(S2021ZDZ042,2023ZDZ06,2024ZDZ08,China).
Insufficient therapeutic strategies for acute kidney injury(AKI)necessitate precision therapy targeting its pathogenesis.This study reveals the new mechanism of the marine-derived anti-AKI agent,piericidin glycoside S...
关键词：Acute kidney injury Piericidin glycoside Peroxiredoxin 1 Nanodrug Kim-1 targeted ADME Marine drug Druggability 
New phenylbutenoids and terpene glycosides from Ginkgo biloba leaves
《Chinese Journal of Natural Medicines》2024年第2期161-170,共10页SUN Zeshi LIN Shan WU Zhi-Li DONG Hong-Yuan XU Xi-Ke LI Hui-Liang WANG Jinxin 
supported by the National Natural Science Foundation of China(Nos.82141203,82003624,82004003,82004215);the Science and Technology Commission of Shanghai Municipality(Nos.20YF1458700,20YF1459000);the Innovation Team and Talents Cultivation Program of National Administration of Traditional Chinese Medicine(No.ZYYCXTDD-202004);Shanghai Frontiers Science Center of TCM Chemical Biology,Shanghai Engineering Research Center for the Preparation of Bioactive Natural Products(No.16DZ2280200).
Our continued works on the chemical constituents of Ginkgo biloba(G.biloba)leaves has led to the isolation of two novel phenylbutenoids(1,2),along with five previously unidentified terpene glycosides(3−7).Among them,c...
关键词：Ginkgo biloba Phenylbutenoid Megastigmane glycoside Bilobanone glycoside 
Chemical approaches for the stereocontrolled synthesis of 1,2-cis-β-D-rhamnosides
《Chinese Journal of Natural Medicines》2023年第12期886-901,共16页CAI Juntao YUAN Xin KONG Yuanfang HU Yulong LI Jieming JIANG Shiqing DONG Chunhong DING Kan 
This work was supported by the Natural Science Foundation of Henan Province(No.232300421374),the Science and Technology Research Project of Henan Province(No.222102310231);the Zhongjing Young Scientist Program of Henan University of Chinese Medicine(No.00104311-2022-1-1-70);the Open Project of Key Laboratory of Carbohydrate Chemistry and Biotechnology,Ministry of Education(No.KLCCB-KF202203);the China Postdoctoral Science Fund Project(No.2021M690936).
In carbohydrate chemistry,the stereoselective synthesis of 1,2-cis-glycosides remains a formidable challenge.This complexity is comparable to the synthesis of 1,2-cis-β-D-mannosides,primarily due to the adverse anome...
关键词：CARBOHYDRATE GLYCOSYLATION 1 2-cis-Glycoside STEREOSELECTIVITY Total synthesis β-Rhamnoside 
The effect and mechanism of stilbene glycosides on improving neuronal injury in Alzheimer's disease rats by regulating ASK/MKK7/JNK pathway
《Journal of Hainan Medical University》2023年第21期1-6,共6页LI Yue KANG Bi-qian HE Xiao-xuan HU Rui XIAO Zhen LUO Chen-liang WU Gui-you HUANG Zhong-shi 
National Natural Science Foundation of China (81860709);Project of Baise City Regional Multiple Development Joint Special Plan[Bai Zi (2022)41-39]。
Objective:To investigate the mechanism of action of tetrahydroxy stilbene glycosides(TSG)in ameliorating neuronal damage in Alzheimer's disease rats by regulating MKK7 and JNK kinases.Methods:A total of 24-month-old 4...
关键词：Nervous system Alzheimer’s disease Stilbene glycoside MKK7 JNK 
Structural mechanism of a dual-functional enzyme Dgp A/B/C as both a C-glycoside cleaving enzyme and an O-to C-glycoside isomerase
《Acta Pharmaceutica Sinica B》2023年第1期246-255,共10页Pengfei He Sha Wang Sen Li Siqi Liu Shuqi Zhou Jing Wang Jiayue Tao Dongdong Wang Rufeng Wang Wenfu Ma 
supported by grants from National Natural Science Foundation of China(No.81073018 and 81274044)to Rufeng Wang;Startup fund program at Beijing University of Chinese Medicine(90011451310011);key research fund for drug discovery in Chinese medicine at Beijing University of Chinese Medicine(1000061223476)to Wenfu Ma。
The C-glycosidic bond that connects the sugar moiety with aglycone is difficult to be broken or made due to its inert nature.The knowledge of C-glycoside breakdown and synthesis is very limited.Recently,the enzyme Dgp...
关键词：C-GLYCOSIDE O-Glycoside C-Glycoside cleaving enzyme ISOMERASE Gut microbiota Flavonoid Puerarin and oxidoreductase 
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