supported by National Natural Science Foundation of China(Grants No.81725023 to Min Ye and 82003614 to Yang Yi);China National Postdoctoral Program for Innovation Talents(No.BX20220022 to Zi-Long Wang).;the Swedish National Infrastructure for Computing(SNIC)at the National Supercomputer Center(SNIC2022-3-34)at Link?ping University(Sweden)。
C-Glycosides are important natural products with various bioactivities.In plant biosynthetic pathways,the C-glycosylation step is usually catalyzed by C-glycosyltransferases(CGTs),and most of them prefer to accept uri...
supported by grants from National Natural Science Foundation of China(No.81073018 and 81274044)to Rufeng Wang;Startup fund program at Beijing University of Chinese Medicine(90011451310011);key research fund for drug discovery in Chinese medicine at Beijing University of Chinese Medicine(1000061223476)to Wenfu Ma。
The C-glycosidic bond that connects the sugar moiety with aglycone is difficult to be broken or made due to its inert nature.The knowledge of C-glycoside breakdown and synthesis is very limited.Recently,the enzyme Dgp...
The experimental studies of this work were funded by NSFC-91753124,NSFC-21672105,NSFC-21421062,and NSFC-21725204 grants.
The C2-α-mannosyl-tryptophan amino acid is produced by a unique posttranslational modification(PTM)of proteins and poses a significant synthetic challenge.A new strategy based on Pd-catalyzed auxiliary-directed remot...
This work was supported by the National Natural Science Foundation of China(21672105,21725204,91753124);Natural Science Foundation of Tianjin(17JCYBJC19700,18JCZDJC32800);the Fundamental Research Funds for the Central Universities(Nankai University)(63191746).
A radical-mediated method was reported for diastereoselective synthesis of non-classical heteroaryl C-glycosides via Minisci-type alkylation of N-heteroarenes with 4-glycosyl-1,4-dihydropyridine(DHP)reagents.These DHP...
A new semi-quinonechalcone C-glycoside isocartormin along with cartormin and saf fl omin C were isolated from the water extract of Carthamus tinctorius L. The structure of isocartormin was determined by extensive anal...
supported by National Natural Science Foundation of China(No.81274190);Jiangsu Provincial Science and Technology Commission(No.BE2012649);Priority Academic Program Development of Jiangsu Higher Education Institutions (PAPD)
Acid hydrolysis mechanisms of orientin-2"-O-galactopyranoside(OGA),orientin and other flavone C-glycosides in the trollflowers[Trollius chinensis Bunge) were studied in this report for the first time.Hydrolysis pa...
supported by the National Natural Science Foundation of China(Nos.30271647,81073005);Shandong Province Young and Middle-Aged Scientists Research Awards Fund(No.BS2010YY032);Scientific Research Foundation for the Returned Overseas Chinese Scholars,State Education Ministry in China(No.42)
This study was conducted to investigate the chemical constituents of Piper wallichii (Miq.) Hand.-Mazz. and evaluate their biological activity. Compounds were isolated by various column chromatographic methods, and ...
A series of new andrographolide C-glycoside derivatives were synthesized by a facile route. The new com- pounds showed higher potency than the parent andrographolide evaluated as a-glycosidase inhibitors in the pre- l...
Objective To study the chemical constituents of Citrullus colocynthis. Methods The chemical constituents were isolated and purified by column chromatography on silica gel and Sephadex LH-20 and recrystallization as we...
Triazolyl phenylalanine and tyrosine-aryl C-glycoside hybrids were readily synthesized via microwave-assisted Cu(I)-catalyzed azide-alkyne 1,3-dipolar cycloaddition in high yields. Successive enzymatic assay identif...