C-GLYCOSIDE

作品数:15被引量:33H指数:4
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相关领域:理学医药卫生更多>>
相关作者:邱声祥宋志军丁立生刘鑫更多>>
相关机构:中国科学院华南植物园中国科学院成都生物研究所更多>>
相关期刊:《分析测试学报》《Chinese Herbal Medicines》《Chinese Journal of Natural Medicines》《Science China Chemistry》更多>>
相关基金:国家自然科学基金天津市自然科学基金更多>>
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A highly selective C-rhamnosyltransferase from Viola tricolor and insights into its mechanisms被引量:2
《Acta Pharmaceutica Sinica B》2023年第8期3535-3544,共10页Bo-Yun Han Zi-Long Wang Junhao Li Qing Jin Hao-Tian Wang Kuan Chen Yang Yi Hansgren Xue Qiao Min Ye 
supported by National Natural Science Foundation of China(Grants No.81725023 to Min Ye and 82003614 to Yang Yi);China National Postdoctoral Program for Innovation Talents(No.BX20220022 to Zi-Long Wang).;the Swedish National Infrastructure for Computing(SNIC)at the National Supercomputer Center(SNIC2022-3-34)at Link?ping University(Sweden)。
C-Glycosides are important natural products with various bioactivities.In plant biosynthetic pathways,the C-glycosylation step is usually catalyzed by C-glycosyltransferases(CGTs),and most of them prefer to accept uri...
关键词:Flavonoid C-glycoside C-rhamnosyltransferase BIOSYNTHESIS Catalytic mechanisms Sugardonorselectivity 
Structural mechanism of a dual-functional enzyme Dgp A/B/C as both a C-glycoside cleaving enzyme and an O-to C-glycoside isomerase
《Acta Pharmaceutica Sinica B》2023年第1期246-255,共10页Pengfei He Sha Wang Sen Li Siqi Liu Shuqi Zhou Jing Wang Jiayue Tao Dongdong Wang Rufeng Wang Wenfu Ma 
supported by grants from National Natural Science Foundation of China(No.81073018 and 81274044)to Rufeng Wang;Startup fund program at Beijing University of Chinese Medicine(90011451310011);key research fund for drug discovery in Chinese medicine at Beijing University of Chinese Medicine(1000061223476)to Wenfu Ma。
The C-glycosidic bond that connects the sugar moiety with aglycone is difficult to be broken or made due to its inert nature.The knowledge of C-glycoside breakdown and synthesis is very limited.Recently,the enzyme Dgp...
关键词:C-GLYCOSIDE O-Glycoside C-Glycoside cleaving enzyme ISOMERASE Gut microbiota Flavonoid Puerarin and oxidoreductase 
Total Synthesis of C-α-Mannosyl Tryptophan via Palladium-Catalyzed C-H Glycosylation被引量:4
《CCS Chemistry》2021年第6期1729-1736,共8页Quanquan Wang Yue Fu Wanjun Zhu Shuang An Qianyi Zhou Shou-Fei Zhu Gang He Peng Liu Gong Chen 
The experimental studies of this work were funded by NSFC-91753124,NSFC-21672105,NSFC-21421062,and NSFC-21725204 grants.
The C2-α-mannosyl-tryptophan amino acid is produced by a unique posttranslational modification(PTM)of proteins and poses a significant synthetic challenge.A new strategy based on Pd-catalyzed auxiliary-directed remot...
关键词:C-GLYCOSIDE C−H glycosylation PALLADIUM AUXILIARY adipokinetic hormone 
Synthesis of non-classical heteroaryl C-glycosides via Minisci-type alkylation of N‑heteroarenes with 4-glycosyl-dihydropyridines被引量:2
《Science China Chemistry》2020年第11期1613-1618,共6页Qingbing Wang Juan Duan Pingping Tang Gong Chen Gang He 
This work was supported by the National Natural Science Foundation of China(21672105,21725204,91753124);Natural Science Foundation of Tianjin(17JCYBJC19700,18JCZDJC32800);the Fundamental Research Funds for the Central Universities(Nankai University)(63191746).
A radical-mediated method was reported for diastereoselective synthesis of non-classical heteroaryl C-glycosides via Minisci-type alkylation of N-heteroarenes with 4-glycosyl-1,4-dihydropyridine(DHP)reagents.These DHP...
关键词:non-classical C-glycoside Minisci reaction 4-gIycosyl-dihydropyridine 
Isocartormin, a novel quinochalcone C-glycoside from Carthamus tinctorius被引量:5
《Acta Pharmaceutica Sinica B》2017年第4期527-531,共5页Feng Li Zhisheng He Yang Ye 
A new semi-quinonechalcone C-glycoside isocartormin along with cartormin and saf fl omin C were isolated from the water extract of Carthamus tinctorius L. The structure of isocartormin was determined by extensive anal...
关键词:Carthamus tinctorius COMPOSITAE Semi-quinone chalcone Cartormin Isocartormin 
Controlled acid hydrolysis and kinetics of flavone C-glycosides from trollflowers被引量:3
《Chinese Chemical Letters》2015年第2期255-258,共4页Mian Dou Xi-Hui He Yan Sun Fang Peng Jiang-Yun Liu Li-Li Hao Shi-Lin Yang 
supported by National Natural Science Foundation of China(No.81274190);Jiangsu Provincial Science and Technology Commission(No.BE2012649);Priority Academic Program Development of Jiangsu Higher Education Institutions (PAPD)
Acid hydrolysis mechanisms of orientin-2"-O-galactopyranoside(OGA),orientin and other flavone C-glycosides in the trollflowers[Trollius chinensis Bunge) were studied in this report for the first time.Hydrolysis pa...
关键词:Flavone C-glycoside Orientin Trollius chinensis Acid hydrolysis Kinetic 
A new flavonol C-glycoside and a rare bioactive lignanamide from Piper wallichii Miq. Hand.-Mazz被引量:4
《Chinese Journal of Natural Medicines》2014年第5期377-381,共5页WANG Pei-Pei ZHAO Guo-Wei XIA Wen HAN En-Ji XIANG Lan 
supported by the National Natural Science Foundation of China(Nos.30271647,81073005);Shandong Province Young and Middle-Aged Scientists Research Awards Fund(No.BS2010YY032);Scientific Research Foundation for the Returned Overseas Chinese Scholars,State Education Ministry in China(No.42)
This study was conducted to investigate the chemical constituents of Piper wallichii (Miq.) Hand.-Mazz. and evaluate their biological activity. Compounds were isolated by various column chromatographic methods, and ...
关键词:Piper wallichii Flavonol C-glycoside Lignanamide DPPH scavenging activity AChE inhibitory activity 
Synthesis and Biological Evaluation of Andrographolide C-Glycoside Derivatives as a-Glycosidase Inhibitors
《Chinese Journal of Chemistry》2012年第4期914-918,共5页严琳 徐海伟 刘丰五 赵瑾 刘宏民 
A series of new andrographolide C-glycoside derivatives were synthesized by a facile route. The new com- pounds showed higher potency than the parent andrographolide evaluated as a-glycosidase inhibitors in the pre- l...
关键词:ANDROGRAPHOLIDE β-C-glycosidic ketone a-glycosidase inhibitor 
A New Flavone C-glycoside from Citrullus colocynthis被引量:5
《Chinese Herbal Medicines》2012年第1期1-3,共3页Jing MIAO Jie ZHANG Shi-ming DENG Bin DAI 
Objective To study the chemical constituents of Citrullus colocynthis. Methods The chemical constituents were isolated and purified by column chromatography on silica gel and Sephadex LH-20 and recrystallization as we...
关键词:CITRULLUS Citrullus colocynthis 6-C-p-methylbenzoylvitexin CUCURBITACIN steride 
Synthesis of Triazole-Linked Amino Acid-Aryl C-Glycoside Hybrids via Click Chemistry as Novel PTPIB Inhibitors
《Chinese Journal of Chemistry》2011年第6期1227-1232,共6页Wang, Jia He, Xiaopeng Gao, Lixin Sheng, Li Shi, Xiaoxin Li, Jia Chen, Guorong 
Triazolyl phenylalanine and tyrosine-aryl C-glycoside hybrids were readily synthesized via microwave-assisted Cu(I)-catalyzed azide-alkyne 1,3-dipolar cycloaddition in high yields. Successive enzymatic assay identif...
关键词:click chemistry C-GLYCOSIDE triazolyl amino acid PTP INHIBITORS 
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