Gastroprotective effect of the iridoid fraction from Barleria prionitis leaves on experimentally-induced gastric ulceration  

作　　者：Sunil K.Jaiswal Mukesh K.Dubey Sanjib Das Ch.V.Rao 

机构地区：[1]Department of Pharmacy,Rameshwaram Institutes of Technology & Management [2]Department of Pharmaceutical Sciences,Dibrugarh University [3]Pharmacognosy & Ethnopharmacology Div.,National Botanical Research Institute (CSIR),Rana Pratap Marg,Lucknow 226001,Uttar Pradesh,India

出　　处：《Chinese Journal of Natural Medicines》2014年第10期738-744,共7页中国天然药物（英文版）

摘　　要：AIM: To study the gastroprotective effect and in vivo antioxidant potential of a standardized iridoid fraction from B. prionitis leaves(BPE) against different gastric ulcer models in rats. METHOD: The standardized iridoid fraction from BPE at 50, 100, and 200 mg/kg body weight was administered orally, twice daily for 5 days for prevention from aspirin, ethanol, cold-restraint stress(CRS), and pylorus ligation(PL)-induced ulcers. Estimation of the antioxidant enzyme activity was carried out in a CRS-induced ulcer model, and various gastric secretion parameters including volume of gastric juice, acid output, and pH value were estimated in the PL-induced ulcer model. RESULTS: BPE showed a dose-dependent ulcer protective effect in PL(18.67%–66.26% protection), aspirin(24.65%–63.25% protection), CRS(20.77%–59.42% protection), and EtOH(16.93%–77.04% protection)-induced ulcers. BPE treatment in PL-rats showed a decrease in acid-pepsin secretion, and enhanced mucin and mucosal glycoproteins. However, BPE reduced the ulcer index with significant decrease in LPO(P < 0.01–0.001), SOD(P < 0.01–0.001), and an increase in CAT(P < 0.01–0.001), activity in the CRS-induced model. CONCLUSION: The data shows that the iridoid fraction from BPE possesses anti-ulcerogenic and antioxidant potential.AIM： To study the gastroprotective effect and in vivo antioxidant potential of a standardized iridoid fraction from B. prionitis leaves（BPE） against different gastric ulcer models in rats. METHOD： The standardized iridoid fraction from BPE at 50, 100, and 200 mg/kg body weight was administered orally, twice daily for 5 days for prevention from aspirin, ethanol, cold-restraint stress（CRS）, and pylorus ligation（PL）-induced ulcers. Estimation of the antioxidant enzyme activity was carried out in a CRS-induced ulcer model, and various gastric secretion parameters including volume of gastric juice, acid output, and pH value were estimated in the PL-induced ulcer model. RESULTS： BPE showed a dose-dependent ulcer protective effect in PL（18.67%–66.26% protection）, aspirin（24.65%–63.25% protection）, CRS（20.77%–59.42% protection）, and EtOH（16.93%–77.04% protection）-induced ulcers. BPE treatment in PL-rats showed a decrease in acid-pepsin secretion, and enhanced mucin and mucosal glycoproteins. However, BPE reduced the ulcer index with significant decrease in LPO（P 〈 0.01–0.001）, SOD（P 〈 0.01–0.001）, and an increase in CAT（P 〈 0.01–0.001）, activity in the CRS-induced model. CONCLUSION： The data shows that the iridoid fraction from BPE possesses anti-ulcerogenic and antioxidant potential.

关 键 词：Barleria prionitis IRIDOID HPTLC Anti-ulcer activity Antioxidant enzymes 

分 类 号：R965[医药卫生—药理学]