Potential prospects of Chinese medicine application in diabetic retinopathy  

作　　者：Yi-Mai Zhou Yuan-Hao Cao Jing Guo Lu-Sha Cen 

机构地区：[1]The First Clinical Medical College,Zhejiang Chinese Medical University,Hangzhou 310053,Zhejiang Province,China [2]Department of Dermatology,The First Affiliated Hospital of Zhejiang Chinese Medical University(Zhejiang Provincial Hospital of Chinese Medicine),Hangzhou 310006,Zhejiang Province,China [3]Department of Ophthalmology,The First Affiliated Hospital of Zhejiang Chinese Medical University(Zhejiang Provincial Hospital of Chinese Medicine),Hangzhou 310006,Zhejiang Province,China

出　　处：《World Journal of Diabetes》2024年第10期2010-2014,共5页世界糖尿病杂志（英文）

基　　金：Supported by National Natural Science Foundation of China,No.82104862;Scientific Research Project Foundation of Zhejiang Chinese Medical University,No.2023FSYYZZ01 and No.2023RCZXZK49.

摘　　要：Current treatment strategies for diabetic retinopathy(DR),an eye condition that can lead to blindness,have mainly focused on proliferative DR,including vitreous injection,retinal photocoagulation,and vitrectomy.Vitreous injections mainly depend on anti-vascular endothelial growth factor therapy.In this editorial,we comment on the article by Sun et al.We focus specifically on the mechanisms of the protective effect of genipin on the retina.Genipin is a gardenia extract used in traditional Chinese medicine(TCM).In their study,the authors suggest that controlling advanced glycosylation by the intraocular injection of genipin may be a strategy for preventing retinopathy.The innovative use of a Chinese medicine extract injected into the eye to achieve a curative effect has attracted our attention.Although TCM is effective in treating DR,the topical application of DR,especially intraocular injections,is not yet feasible.Herein,we present a brief analysis of effective Chinese medicines for the treatment of DR.The effectiveness of local injections of TCM applied directly into the eyes holds promise as an effective treatment approach for DR.

关 键 词：Diabetic retinopathy Traditional Chinese medicine GENIPIN Topical application Advanced glycation end products 

分 类 号：R587.2[医药卫生—内分泌] R774.1[医药卫生—内科学]