肺癌MRI信号与癌细胞核DNA含量的研究  

Investigation on the relationship of MRI signal and DNA content of lung cancer

作　　者：许冬明[1] 陈九如[1] 杨振燕[2] 汤如勇[3] 詹松华[2] 李日乐[3] 

机构地区：[1]上海市闸北区中心医院放射科,上海200070 [2]上海铁道大学医学院附属甘泉医院放射科 [3]上海铁道大学医学院附属甘泉医院病理科

出　　处：《中国临床医学影像杂志》1999年第4期251-253,共3页Journal of China Clinic Medical Imaging

摘　　要：目的：通过MRI及细胞图像分析仪，探讨原发性支气管肺癌MRI信号与DNA倍体的关系。材料与方法：23例原发性支气管肺癌患者，于术前2周，行Resonex0．38T磁共振成像（横断面SET1WI、GR、增强后SET1WI）。术后标本用ICM－100细胞图像分析仪，测定每例肺癌标本的DNA含量及SPF值。结果：T1加权平扫二倍体肿瘤信号强度比（病变／椎体）显著小于异倍体肿瘤的信号强度比。二倍体肿瘤的SPF值也显著小于异倍体肿瘤的SPF值。但MRI信号强度比不能反映肺癌的SPF值。结论：MRI信号强度在一定程度上可反映肿瘤细胞的倍体情况，即可间接地反映肿瘤细胞的生物学行为。Objective: To explore the relationship of MRI signal and DNA content of lung cancer. Materials and Methods: Twentythree cases of lung cancer proved by surgery and pathology were examined with a 0. 38T MR system before operation. The pulse sequencesinclude SE T1 WI, gradient echo and gadolinium(Dd - DTPA) - enhanced SE T1 WI sequences. DNA content was measured by a imaging analyzer(ICM - 100) and the SPF percentage (S Phase Fraction)was calculated. Results: Signal - intensity ratios of lesion to vertebra on unenhanced SE T1 WI and SPF percentage were significantly smaller in diploid lesions than in aneuploid lesions. But MRI signal intensity ratioscan not reflect SPF status. Conclusion: MRl signal - intensity ratios can reflect DNA ploidy in a certain degree, so it can indirectly reflectthe malignant biological behavior of lung cancer.

关 键 词：肺癌 MRI信号 DNA含量 S期分数 癌细胞核 

分 类 号：R734.202[医药卫生—肿瘤]