CIK细胞及LAK细胞对小鼠克洛氏肉瘤作用的实验研究  被引量:4

Anti-tumor activity of CIK cells and LAK cells on the mice bearing S_(180) sarcoma in vivo

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作  者:邢淑贤[1] 宋英晖[1] 任欢[1] 徐红薇[1] 张宇阳[1] 李殿俊[1] 

机构地区:[1]哈尔滨医科大学免疫学教研室,黑龙江哈尔滨150086

出  处:《哈尔滨医科大学学报》1999年第4期259-261,共3页Journal of Harbin Medical University

摘  要:通过向PBMC中加入IFN-γ、IL-2、IL-1α及抗CD3单克隆抗体,诱导出高效免疫活性细胞团子激活的杀伤细胞(Cytokine-inducedkillercells,CIK),并建立了小鼠克洛氏肉瘤(S_(180))荷瘤动物模型,证实CIK过继免疫疗法具有显著的抗肿瘤作用,其抑瘤率可达78%;并同时以LAK细胞作为对照,LAK组的抑瘤率为对33.70%,明显低于CIK组13.30%(p<O.05)。In this paper, the highly efficient cytolytic effector cells termed CIK (cytokine - inducedkiller) cells were generated by culturing PBMC in the presence of IFN-γ IL-2 IL-1α and McAb againstCD3 .The mice bearing S_(180) sarcoma was used to evaluate the anti-tumor effects of CIK and LAK cells invivo .The results showed that CIK cells had significanily anti-tumor effects (the median inhibitory rate was78% ). It suggested that CIK therapy was correlated with inducing the proliferation of spleen T cells otherthan the NK cytolytic activity.

关 键 词:CIK细胞 细胞因子 肿瘤 免疫疗法 

分 类 号:R730.5[医药卫生—肿瘤]

 

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