不同ER-β基因型绝经妇女补充大豆异黄酮和钙后血脂的变化  

Changes of serum lipids after soy isoflavone and calcium supplementation in postmenopausal Chinese women with different ER-β genotypes

作　　者：黄振武[1] 董杰[1] 曾晶[2] 李卫东[2] 杨晓光[1] 龚洁[2] 

机构地区：[1]中国疾病预防控制中心营养与食品安全所,北京100050 [2]武汉市疾病预防控制中心

出　　处：《卫生研究》2011年第3期280-282,共3页Journal of Hygiene Research

基　　金：国家科技支撑计划课题(No.2008BAI58B02);国家自然科学基金项目(No.30300286)

摘　　要：目的观察血脂正常的不同ER基因型的绝经妇女补充钙和大豆异黄酮片剂(不含蛋白)一年后血脂的变化。方法从武汉郊区绝经妇女中筛选60名血脂正常但骨量减少或骨质疏松的绝经妇女为受试对象,随机分为两组,每组各30人,并确定其ER-β基因型别。一组给予液体钙440mg/d,VD 100IU/d;另一组给予液体钙440mg/d,VD 100IU/d和大豆异黄酮片剂100mg/d(不含蛋白),随访一年。测定每位受试对象各血脂成分,包括甘油三酯(TG)、总胆固醇(CHO)、低密度脂蛋白胆固醇(LDL)和高密度脂蛋白胆固醇(HDL)。结果补钙和补钙+大豆异黄酮组的血总胆固醇均显著降低(P<0.05)。在Rr/rr基因型绝经妇女中,补钙组TG平均增加了0.2mmol/L,补钙+大豆异黄酮组平均降低了0.44mmol/L,两者间差异有显著性(P<0.05)。结论足量的钙和适量的大豆异黄酮摄入不仅有益于绝经妇女的骨骼代谢,还有益于血脂代谢,且随ER-β基因酶切型别的不同而异。Objective To observe the change of blood lipids after one-year of soy isoflavone and calcium supplementation in postmenopausal Chinese women with different ER-β genotypes.Methods Sixty postmenopausal women with normal serum lipid levels but with bone loss or even osteoporosis were selected from Wuhan.The ER-β genotypes of subjects were identified.The subjects were randomly divided into two groups,groupⅠwas given 440mg/d calcium and VD 100IU/d and groupⅡ was given calcium 440mg/d,VD 100IU/d and soy isoflavone 100mg/d for one year.Serum lipids,including TG,CHO,LDL and HDL were measured before and 12 months after intervention.Result Total cholesterol was decreased both in group Ⅰ and group Ⅱ（P0.05）.The change of serum TG was significantly different between groupⅠand groupⅡ in subjects with Rr/rr genotype（0.20±0.41 and 0.44±0.93,P0.05）.Conclusion Rational intervention with calcium and soy isoflavone for postmenopausal women might be in favor of their health in bone and blood lipids metabolism,but the effects might be varied by different ER-β genotypes.

关 键 词：ER-β基因型别 绝经妇女 血脂 大豆异典酮 钙 

分 类 号：R153.1[医药卫生—营养与食品卫生学]