4种常见ER联合基因型哺乳妇女断奶补钙后的骨密度变化  

Effect of calcium supplementation on the regain of BMD in Chinese lactating women with 4 major combined ER genotypes

作　　者：于波[1] 李芳[2] 龚洁[2] 曾晶[2] 周墩金[2] 杨晓光[1] 黄振武[1] 

机构地区：[1]中国疾病预防控制中心营养与食品安全所,北京100050 [2]武汉市疾病预防控制中心

出　　处：《卫生研究》2011年第3期320-322,共3页Journal of Hygiene Research

基　　金：国家科技支撑计划课题(No.2008BAI58B02);国家自然科学基金资助项目(No.30571573)

摘　　要：目的观察常见ER基因联合型妇女的骨密度在断奶补钙后的自我恢复状况,以及补钙对其骨密度的影响。方法在湖北省武汉地区满月产妇中筛选雌激素受体(ER)基因代表型ppxx、Ppxx、PpXX和PPXx各40名,每种基因型别产妇随机分为2组,一组为补钙组(每日600mg钙,碳酸钙),另一组为对照组。产后3个月时,使用双能X线吸收骨密度测定仪测量母亲腰椎和左髋基线骨密度,并通过3d、24h的膳食调查计算其平均每日钙摄入量,随即补钙(补钙组)或给予安慰剂(对照组),1年后再次测定相同部位的骨密度。结果所有产妇,无论补钙与否,1年后腰椎和左髋的骨密度都增加或显著增加(P<0.05)。与对照组相比,仅ppxx型产妇补钙后左髋骨密度增加率差异没有显著性(P>0.05),其余型别产妇差异均有显著性(P<0.05)。逐步回归分析表明,产妇哺乳时间是髋部骨密度增加率的主要影响因素。结论尽管武汉地区产妇的钙日摄入量较少,产后3个月起的1年内其腰椎和左髋骨密度仍明显增加;补钙至少对某些ER等位基因代表型产妇有益。0bjective To observe the regain of bone mineral density（BMD） in Chinese lactating women with 4 major combined ER genotypes（defined as Pvu II and Xba I）.Methods A total of 160 healthy lactating women was selected,40 women with each of 4 genotypes（ppxx,Ppxx,PpXX or PPXx） were divided into a calcium supplement group received 600mg calcium（as CaCO3） daily,and a control group.BMD of lumbar spine and left hip were measured by dual energy X-ray absorption bone densitometry on 3 months and one year after delivery.Calcium intake was calculated from a 3 days dietary recall.Results Whether supplementing calcium or not,the BMD of these women increased obviously（P0.05）.The less BMD regaining at hip was observed in women with ppxx genotype than those with Ppxx or PPXx genotype（P0.05）when 600mg calcium was given daily.Calcium supplementation and the duration of lactation were significantly related to hip BMD via a stepwise linear regression analysis（the standardized coefficient was 0.227,and P value was 0.007）.Conclusion Although the dietary calcium intake was low in Wuhan lactating women,the BMD of lumbar spine or of left hip of women with some genotypes was increased greatly by calcium supplementation.

关 键 词：ER等位基因 哺乳 骨密度 补钙 产妇 

分 类 号：R153.1[医药卫生—营养与食品卫生学]