博来霉素单药方案治疗癌性胸腔积液32例临床疗效  

Efficiency of Bleomycin in treatment of 32 patient with malignant pleural effusion

作　　者：刘艳良[1] 张红霞[1] 

机构地区：[1]秦皇岛市第二医院肿瘤内科,河北昌黎066600

出　　处：《中国医药导报》2011年第15期89-90,共2页China Medical Herald

摘　　要：目的:观察博来霉素单药胸腔内注射治疗癌性胸腔积液的临床疗效。方法:对我院2008～2010年的32例癌性胸腔积液的患者采用胸腔置管,将胸腔积液充分引流后局部注入博来霉素治疗,如第一次给药后5～7 d胸腔积液未控制,可再重复一次。2周为1个疗程。结果:博来霉素单药治疗癌性胸腔积液有效率为78%(25/32);治疗后KPS评分提高,与治疗前比较差异有统计学意义(P<0.05)。结论:博来霉素单药治疗癌性胸腔积液疗效显著,能提高患者的生活质量,且毒副作用少,是治疗癌性胸腔积液的有效方法。Objective：To investigate the clinical effect of Bleomycin in the treatment of patients with malignant pleural effusion.Methods：32 cases of malignant pleural effusion with thoracic drainage were injected by Bleomycin after sufficient drainage.5-7 days later,the patients who still had pleural effusion received the second pleurodesis.Results：The effective rate was 78%（25/32）;while the KPS scores decreased significantly after treatment compared with before treatment（P0.05）.Conclusion：The effect of Bleomycin in the treatment of patients with malignant pleural effusion is effective with low toxicity,thus it serves as an effective regimen for malignant plural effusion.

关 键 词：博来霉素 癌性胸腔积液 疗效 

分 类 号：R730.53[医药卫生—肿瘤]