异甘草酸镁治疗失代偿期肝硬化的疗效观察  

Effect of magnesium isoglycyrrhizinate on liver cirrhosis of decompensated stage

作　　者：田国华[1] 张国顺[1] 王玉兰[1] 张学军[1] 马宁[1] 

机构地区：[1]河北联合大学附属医院消化内科,唐山063000

出　　处：《中国综合临床》2011年第5期458-460,共3页Clinical Medicine of China

基　　金：唐山市临床医学研究计划项目（08130201C）

摘　　要：目的探讨异甘草酸镁治疗失代偿期肝硬化的疗效。方法失代偿期肝硬化患者86例，随机分为2组，均给予常规综合治疗，43例加用异甘草酸镁注射液150mg，其余43例加用复方甘草酸单铵注射液80mg，均采用5％葡萄糖注射液250ml稀释后静脉滴注，1次／d。观察2组患者症状、体征及肝功能变化，治疗前后进行血常规、尿常规和肾功能检查，并随时记录药物不良反应。结果异甘草酸镁组和复方甘草酸单铵组治疗后肝功能复常率[ALT复常率：97．7％（42／43）、72．1％（31／43），AST复常率：90．7％（39／43）、74．4％（32／43），x^2值分别为9．86、4．73]和肝功能复常时间[ALT复常时间：（21．6±9．1）、（37．5±17．8）d，AST复常时间：（23．1±10．6）、（46．7±19．4）d，t值分别为5．23、7．01]比较差异均有统计学意义（P均〈0．01）。结论异甘草酸镁治疗失代偿期肝硬化在改善症状和降酶方面疗效更佳。Objective To compare the curative effect of magnesium isoglycyrrhizinate and compound ammonium glycyrrhetate in patients with liver cirrhosis of decompensated. Methods Eighty-six patients with liver cirrhosis of decompensated were enrolled into the study and randomly divided into two groups： the treatment group （n = 43） were given magnesium isoglycyrrhizinate once a day in addition to routine treatment;the control group（n =43） were given compound ammonium glyeyrrhetate once a day in addition to routine treatment. The clinical manifestation, including symptoms, signs and hepatic function were observed. The clinical lab data, including blood routine examination, urine routine test and kidney function of all patients from two groups were collected before and after the treatments. The adverse drug reactions were monitored throughout the whole therapy. Results ALT and AST turned to normal in 97. 7% （42/43） and 90.7% （39/43） of patients respectively in the treatment group,which were significantly higher than those of 72. 1% （31/43） and 74.4% （32/43） respectively in the control group（ X^2 =9. 86 and 4. 73,respectively,Ps 〈0. 05）. Time to turning to normal in ALT and AST were （ 21.6 ±9. 1 ） d and （ 23.1±10. 6 ） d in the treatment group, which were significantly lower than those of（ 37.5± 17. 8 ）d, and （46, 7 ± 19.4 ）d respectively in the control group （t = 5.23 and 7.01 ,respectively,Ps 〈 0. 01 ）. Conclusion The results suggested that magnesium isoglyeyrrhizinate had better effect on alleviating symptoms and decreasing enzyme in treatment of liver cirrhosis of decompensated stage.

关 键 词：肝硬化 异甘草酸镁 复方甘草酸单铵 

分 类 号：R575.2[医药卫生—消化系统]