偏头痛实验动物模型的研究现状  

The Current Research Situation of Experimental Animal Models of Migraine

作　　者：袁博博[1] 罗国刚[1] 

机构地区：[1]西安交通大学医学院第一附属医院神经内科,西安710061

出　　处：《医学综述》2011年第10期1447-1450,共4页Medical Recapitulate

基　　金：国家自然科学基金(30570631);西安交通大学国际交流与合作重点项目(0702-07)

摘　　要：偏头痛是一种由体外触发和体内病理生理机制相互作用、伴有神经心理及胃肠症状、具有遗传性及复发性的头痛综合征。其发病机制至今尚未完全明了,动物模型基于三叉神经血管学说、皮层扩散抑制学说和血管学说等理论而建立。现从造模机制、特点、适用范围及效度等方面对目前常用的偏头痛动物模型的研究现状进行综述。Migraine is a genetically related recurrent headache syndrome appearing with neuro-psychological and gastrointestinal symptoms,implicating interaction between external triggers and internal pathophysiology.Its pathogenesis is still not completely clarified,animal models are established on the basis of trigeminovascular theory,cortical spreading depression theory and neurovascular theory.Here is to review the current migraine experimental animal models from the perspectives of modeling mechanism,characteristics,scope and validity,etc.

关 键 词：偏头痛 动物 疾病模型 

分 类 号：R747.2[医药卫生—神经病学与精神病学]