新型席夫碱的合成及其抑菌活性  

Synthesis of Novel Schiff Bases and Their Antibacterial Activities

作　　者：朱万仁[1] 李家贵[1] 陈渊[1] 陈光全[1] 朱宇林[1] 黄肇宇[1] 彭昌顺[1] 林广芝[1] 吴德娟[1] 

机构地区：[1]玉林师范学院化学与生物系,广西玉林537000

出　　处：《合成化学》2011年第3期341-344,共4页Chinese Journal of Synthetic Chemistry

基　　金：广西自然科学基金资助项目(桂科自0640207)

摘　　要：以2,6-二甲基吡啶为原料合成了关键中间体2,6-吡啶二甲酰肼(3);3分别与醛或酮反应制得了一系列新型席夫碱(1a～1f),产率50%～97%,其结构经UV,NMR,IR和MS表征。初步生物活性测试结果表明,1对金黄色葡萄球菌、变形杆菌、大肠杆菌和芽孢杆菌均具有一定的抑菌活性,其中1d的抑菌活性最高。The key intermediate,2,6-pyridinebiformyl hydrazine（3）,was synthesized from 2,6-dimethyl pyridine.Six novel Schiff bases（1a～1f） in yields of 50%～97% were prepared by the reaction of 3 with aldehydes or ketones,respectively.The structures were characterized by UV,NMR,IR and MS.The preliminary antibacterial tests showed that 1 exhibited antibacterial activity to staphylococcus aureus,proteus,colibacillus and bacillus,1d was the best of all.

关 键 词：2 6-吡啶二甲酰肼 席夫碱 合成 抑菌活性 

分 类 号：O625.63[理学—有机化学]