慢性阿片类物质依赖者额叶白质完整性的DTI研究  

A Diffusion Tensor Imaging for Whiter Matter Integrity of Frontal Lobe in Chronic Opiate Dependence

作　　者：李玮[1] 王亚蓉[1] 李强[1] 朱佳[1] 杨伟川[1] 熊小双[1] 王玮[1] 

机构地区：[1]第四军医大学唐都医院放射科,西安710038

出　　处：《临床放射学杂志》2011年第4期477-480,共4页Journal of Clinical Radiology

基　　金：国家自然科学基金资助项目(基金编号:30870685);陕西省科学技术研究发展计划项目(编号:2010K16-03-02)

摘　　要：目的观察慢性阿片类物质依赖者额叶白质微结构,探讨其脑功能损害的结构病理基础。资料与方法搜集慢性阿片类物质依赖者27例(OD组),健康受试者15名(C组),行头颅扩散张量成像(DTI)检查,运用感兴趣区的方法分别测量双侧额叶连续4个层面上各向异性分数(fractional anisotropy,FA)、表观扩散系数(ADC)及平行(λ∥)和垂直(λ⊥)方向的本征值,采用两样本t检验的方法观察组间各指标的差异。结果与C组相比,OD组双侧额叶FA值降低,λ⊥升高,组间差异具有统计学意义(P<0.05);而ADC值和λ∥在两组间差异无统计学意义。结论慢性阿片类物质依赖者双侧额叶白质完整性破坏,且以髓鞘破坏为主,这可能成为造成依赖者脑功能异常的部分原因。Objective To observe the microstructure of whiter matter in chronic opiate dependence,and to explore the potential structural pathological alteration of functional impaires.Materials and Methods 27 chronic opiate dependence（OD group） and 15 healthy controls（C group） were enrolled to receive diffusion tensor imaging examination.The regions of interest were placed on whiter matter of 4 continuous slices of bilateral frontal,fractional anisotropy（FA）,apparent diffusion coefficient（ADC） and eigenvalues（λ⊥,λ∥） were measured.Two-sample t-test was used to compare the whiter matter integrity of bilateral frontal lobe between two groups.Results Opiate dependent patients had reduced FA and increased λ⊥ in bilateral frontal lobe compared with controls,there was statistical significant difference between two groups（P0.05）,but there was no significant difference in ADC and λ∥ between two groups.Conclusion The whiter matter integrity of bilateral frontal lobe is disrupted in chronic opiate dependence,and myelinopathy rather than axonal injury maybe the dominant pathological feature.

关 键 词：阿片类物质依赖 海洛因 美沙酮 扩散张量成像 

分 类 号：R749.6[医药卫生—神经病学与精神病学]