620个宫腔内人工授精周期临床妊娠结局探讨  

An analysis of clinic outcomes of 620 intrauterine artificial insemination cycles

作　　者：曹善仁[1] 张军强[1] 凌秀凤[1] 李秀玲[1] 黄美玲 赵静[1] 童国庆[1,2] 

机构地区：[1]南京医科大学附属南京妇幼保健院生殖医学中心,江苏南京210004 [2]同济大学附属第一妇婴保健院生殖医学中心,上海200040

出　　处：《生殖医学杂志》2011年第2期116-118,共3页Journal of Reproductive Medicine

摘　　要：目的 探讨患者年龄,周期数和注入宫腔内前向运动精子总数（NMSI）对宫腔内人工受精（IUI）临床妊娠率的影响.方法 339对夫妇的620个IUI周期,按年龄分为：≤35、35～40、≥40岁组;按周期数分为：第1个、第2个、第3及〉第3个周期;按处理后NMSI分为：〈2、2～5、5～10、10～20及〉20×106组,分别比较各组间的临床妊娠率差别,分析各因素对IUI临床妊娠结局的影响.结果 年龄≤35、35～40及≥40岁组临床妊娠率分别为14.52、17.85及0.00%;第1、第2、第3及〉3个周期临床妊娠率分别为13.86%、18.82%、12.64%及0.00%;NMSI〈2、2～5、5～10、10～20及〉20×106 组临床妊娠率分别为3.13%、18.18%、13.21%、14.83%及16.00%.结论 年龄＞40岁,处理后前向运动精子总数低于2×106,以及3～4次IUI尝试仍未成功的患者,不适合继续尝试IUI治疗.Objective： To explore the effects of female patients＇ age, number of intrauterine artificial insemination （IUI） cycle and number of motile spermatozoa inseminated （NMSI） on the clinical pregnancy outcomes of IUI treatment. Methods： A total of 620 IUI cycles of 339 couples accomplished in this Center were retrospectively studied. The cycles were grouped according to patients＇ age （≤35, 35-40 and ≥40 years）, number of IUI cycle （the first, the second, the third cycle and more than 3 cycles） and NMSI （-（2, 2-5, 5-10, 10-20 and 〉20 × 10^8） , respectively. The pregnancy rates between groups were compared. Results： The pregnancy rates of the patients aged ≤35, 35-40 and ≥40 years were 14.52%, 17.85% and 0.00%, respectively. The pregnancy rates in the groups of the first cycle, the second cycle, the third cycle and more than 3 cycles were 13.86%, 18.82%, 12.64% and 0.00%, respectively. The pregnancy rates in the groups with NMSI 〈2, 2-5, 5-10, 10-20 and 〉20×10^6 were 3. 13%, 18. 18%, 13.21%, 14.83% and 16.00%, respectively. Conclusions： The patients over 40 years of age, or with 〈2 × 10^6 total motile spermatozoa counts for insemination, or with 3 or more failed IUI cycles, were not suitable for IUI treatment.

关 键 词：宫腔内人工授精 年龄 周期数 注入宫腔内前向运动精子总数 

分 类 号：R[医药卫生]