植物来源的抗肿瘤药物研究进展  

Progresses in Study on the Plant-originated Anti-tumor Drugs

作　　者：王超磊[1,2] 孙炳峰[2] 姚和权[1] 吴晓明[1] 徐进宜[1] 

机构地区：[1]中国药科大学药学院,江苏南京210009 [2]中国科学院上海有机化学研究所,上海200032

出　　处：《药学进展》2011年第5期193-202,共10页Progress in Pharmaceutical Sciences

基　　金：国家自然科学基金项目(No.30973610);教育部科学技术研究重点项目(No.108069)

摘　　要：综述喜树碱、紫杉醇、鬼臼毒素和combretastatin A-4等4类植物来源的抗肿瘤药物的作用机制、构效关系及衍生物的研究进展。植物来源的抗肿瘤药物已逐步在临床肿瘤治疗领域占据主导地位,而充分利用我国丰富的药用植物资源,研发高效低毒的天然抗肿瘤药物也已成为广大药学工作者的热点课题。The recent progresses in the mechanism of action and structure-activity relationship of four classes of the plant-originated anti-tumor drugs,camptotherins,paclitaxels,podophyllotoxins and combre-tastatin A-4,as well as their derivatives have been summerized in this paper.The plant-originated anti-tumor drugs have been gradually dominated in the clinical cancer treatment.Taking full advantage of rich resources of medicinal plants in China and developing new natural anti-tumor drugs with high activity and low toxicity have now become a hot topic studied by pharmaceutical researchers.

关 键 词：天然活性产物 结构修饰 衍生物 抗肿瘤活性 作用机制 构效关系 

分 类 号：R93[医药卫生—生药学]