蝇蛆干粉营养素含量及蝇蛆壳聚糖对实验性糖尿病大鼠抗氧化损伤能力影响的研究  

Study on the Determination of Nutrient Contents of Fly Maggot Powder and the Effect of Flyblow Chitosan on Anti-oxidant Function in Experimental Diabetic Rats.

作　　者：陈林军[1] 冯晓慧[2] 蔡东联[2] 林宁[2] 曲丹[2] 金迪[2] 郑慧[2] 王洁[2] 

机构地区：[1]上海市职工医学院公共卫生系,200234 [2]第二军医大学附属长海医院临床营养科,上第200433

出　　处：《医学研究杂志》2011年第4期49-51,共3页Journal of Medical Research

基　　金：上海市科学技术委员会科技攻关项目基金资助(04DZ19506)

摘　　要：目的本研究分析蝇蛆干粉营养素含量,并研究蝇蛆壳聚糖对实验性糖尿病的抗氧化损伤能力和可能的机制。方法用化学等方法测定各种营养素的含量,用试剂盒测定血清超氧化物歧化酶(SOD)、谷胱甘肽过氧化物酶(GSH-Px)的活性及丙二醛(MDA)含量。结果蝇蛆干粉营养丰富,蛋白质61.4%,脂肪达12.3%,壳聚糖为10.8%。蝇蛆壳聚糖对实验性高血糖大鼠的作用与模型对照组相比,中、高剂量组血清SOD活性明显提高,其中中剂量组相差显著(P<0.05),高剂量组非常显著(P<0.01);中、高剂量组血清GSH-Px活性有明显的提高,中、高剂量组均有非常显著的差异(P<0.01);中、高剂量组血清MDA含量有明显下降,差异非常显著(P<0.01)。结论蝇蛆干粉营养丰富,蛆壳聚糖对实验性糖尿病有显著的抗氧化损伤能力。Objective To determine the nutrient contents of fly maggot powder,as well as to explore the effect and possible mechanisms of flyblow chitosan on anti-oxidation.Methods The contents of nutrients were analyzed by chemical methods.The activity of SOD,GSH-Px,MOD were analyzed through the method of kit.Results Fly maggot powder was rich in nutrition,with 61.4% of protein,12.3% of fatty,and 10.8% of flyblow chitosan.The activity of SOD in medium-and high-dose groups increased significantly compared with the control group,with the medium-dose group witnessed significant difference（P0.05） and the high-dose group witnessed highly significant difference（P〈0.01）.The activity of GSH-Px also increased significantly in both medium-and high-dose groups（P〈0.01）.The serum MDA content decreased significantly in both medium-and high-dose groups（P〈0.01）.Conclusion The fly maggot powder is rich in nutrition.Flyblow chitosan has significant anti-oxidant capability.

关 键 词：蝇蛆干粉 营养素 蝇蛆壳聚糖 实验性糖尿病大鼠 

分 类 号：R285.5[医药卫生—中药学]