碳酸酐酶Ⅲ在疾病和肌肉疲劳发生发展中的作用  

Effects of CAⅢ on the occurrence and development of diseases and muscle fatigue

作　　者：尚西亮[1] 鲍苑苑[2] 任惠民[3] 陈世益[1] 

机构地区：[1]复旦大学附属华山医院运动医学科,上海200040 [2]复旦大学附属华山医院内分泌科,上海200040 [3]复旦大学神经病学研究所,上海200040

出　　处：《生命科学》2011年第5期429-433,共5页Chinese Bulletin of Life Sciences

基　　金：国家自然科学基金项目(30771044);复旦大学青年科学基金项目(09FQ66)

摘　　要：碳酸酐酶(carbonic anhydrases,CAs)是一种广泛存在的含锌的金属蛋白酶,能可逆性地高效催化CO2的水合反应,参与调节胞内pH值、离子运输和生物合成反应等多种生理过程。在哺乳动物体内已发现13种CA同工酶和3种CA相关蛋白,其中CAⅢ与其他CA同工酶相比,在组织分布、分子结构和生物学功能上均有其独特之处。CAⅢ表达异常可能与多种临床疾病的发生和发展有关,还可能参与了肌肉疲劳的发生。Carbonic anhydrases（CAs） are zinc metalloenzymes that catalyze the reversible hydration of CO2 to bicarbonate.They are major players in many physiological processes,including pH regulation and homeostasis,ion transportation,biosynthetic reactions,etc.The CA family consists of 13 different CA isozymes and 3 different CA-related proteins（CARP）.Carbonic anhydrase Ⅲ（CAⅢ） is one specific member of this family,which distinguished from the other isozymes by tissue distribution,molecular structure and biological functions.In recent years,it has been suggested that the changes of protein levels and activities of CAIII might be related with the occurrence and development of many kinds of diseases and muscle fatigue.

关 键 词：碳酸酐酶Ⅲ 生物学功能 疾病 肌肉疲劳 

分 类 号：Q556[生物学—生物化学] R363.14[医药卫生—病理学]