防城港市成年男性非酒精性脂肪肝患病率及其危险因素分析研究  

Analysis of the Prevalence of Nonalcoholic Fatty Liver Disease and its Risk Factors in a General Adult Males of Fangchenggang City

作　　者：孙宇[1] 李智贤[1] 莫曾南[1] 丁雪明[1] 郭蔷[1] 田桂湘[1] 陈力 张海英[3] 杨晓波[3] 高勇[1] 

机构地区：[1]广西医科大学第一附属医院 [2]广西防城港市第一人民医院,防城港市538021 [3]广西医科大学公共卫生学院,南宁市530021

出　　处：《广西医学》2011年第4期389-392,共4页Guangxi Medical Journal

基　　金：国家自然科学基金(30945204);国家"十一五"科技支撑计划项目基金(2007BAI07A17-11)

摘　　要：目的了解一般人群成年男性非酒精性脂肪肝(NAFLD)的患病率,分析其危险因素。方法以参加防城港市第一人民医院体检的男性人群作为研究对象,内容涉及问卷、一般体格检查、血生化检测及肝脏实时超声检查,筛选出3 238例有完整调查问卷和检查资料的成年男性进行研究。结果 3 238例中检出NAFLD832例,患病率为25.69%。男性50岁以前NAFLD患病率均随年龄增长而增加,而5岁以后逐渐下降。NAFLD组年龄、腰围、体重指数(BMI)、腰臀比、收缩压、舒张压、空腹血糖(FPG)、总胆固醇(TC)、三酰甘油(TG)、低密度脂蛋白胆固醇(LDL-C)、谷丙转氨酶(ALT)、尿酸(UA)以及超重、肥胖、高TC血症、高TG血症、空腹血糖受损、糖尿病、高血压症、高UA血症和肝功能异常的检出率均明显高于对照组,高密度脂蛋白胆固醇(HDL-C)低于对照组。Logistic回归分析显示TG、BMI、腰围、FPG、HDL-C、ALT、UA与男性NAFLD的发生密切相关(P<0.05)。结论防城港市成年男性NAFLD患病率高,TG、BMI、腰围、FPG是男性患NAFLD的危险因素,HDL-C是其保护因素。Objective To investigate the prevalence rate of nonalcoholic fatty liver disease（NAFLD）and its risk factors among adult males in a general population.Methods The large-scale physical examination were conducted for statistical analysis in Fangchenggang First People＇s Hospital.A standard interview,anthropometrics,iochemical studies,and abdominal ultrasonography were required for each participant.Results A total of 3 238 cases of adult men enrolled in the survey,of 832 individuals was diagnosed as NAFLD（25.69%）,while 2 406 healthy subjects were designated as the control group.Among adult males younger than 50 years,the prevalence of NAFLD increased with age,but in participants older than 50 years the case was just the opposite.The mean age,waist circumference,body mass index（BMI）,waist-to-hipratio,contractive pressure,diastolic pressure,fasting plasma glucose（FPG）,total cholesterol（TC）,triglyceride（TG）,low density lipoprotein cholesterol（LDL-C）,ALT,uric acid（UA）,and the presence of overweigh,obesity,hypercholesteremia,hypertriglyceridemia,impairedfasting glucose,diabetes mellitus,hypertension,hyperuricemia,liver dysfunction in NAFLD group was significantly higher than those in control group,but the high density lipoprotein cholesterol（HDL-C）level in NAFLD group was lower than that of control group.Logistic regression showed that TG,BMI,waist circumference,FPG,HDL-C,ALT and UA were highly correlated to NALFD.Conclusion There is a high prevalence of NAFLD among adult males in Fangchenggang.The risk factors for NAFLD are TG,BMI,waist circumference and FPG.HDL-C is the protective factor for NALFD.

关 键 词：非酒精性脂肪肝 患病率 危险因素 超声诊断 防城港市 

分 类 号：R575.5[医药卫生—消化系统]