二硫化碳对雌性小鼠受精卵发育及染色体的影响  

The Effects of Carbon Disulphide on Development and Chromosome of Fertilized ova of Mice

作　　者：保毓书[1] 蒋衡[1] 郑青[1] 于永强[2] 高敏 邵华 

机构地区：[1]北京医科大学公共卫生学院 [2]化学工业部劳动保护研究所

出　　处：《卫生毒理学杂志》1990年第3期139-141,共3页Journal of Health Toxicology

摘　　要：用昆明种性成熟雌性小鼠,以10mg/m^3及100mg/m^3浓度CS_2吸入染毒,每日2小时,每周6天,染毒3周(相当3～4个动情周期)后给雌小鼠腹腔注射孕马血清及HCG,令超数排卵,并与未经染毒雄性小鼠交配。后处死小鼠,检查受精卵并制备染色体标本。结果,两个染毒组,发育异常卵出现率显著高于对照组,雌原核染色体畸变的受精卵出现率也显著高于对照组。Kunming adult female mice were exposed to CS2 at concentrations of O, 10 and 100mg/m3 for 2 hours/day, 6 days/week for 3 weeks ( about 3-4 estrous Cycles) . After exposure, the mice were injected intraperitoneally with PMSG and HCG and then were mated with anexposed male mice. After mating, mice were sacrificed. The fertilized ova were examined and chromosomal specimens were prepared. The results indicated that the incidence of maldevelopmental ova of the two exposed groups was higher than that of the control group ( P<0.05 ) , and the incidence of fertilized ova with female pronucleus chromosomal aberration was higher than that of the control group also ( P<0.005 ) .

关 键 词：二硫化碳 受精卵 发育 染色体畸变 

分 类 号：R114[医药卫生—卫生毒理学]