行为干预对氯氮平所致代谢紊乱的疗效分析  

Efficacy of behavioral intervention in the treatment of clozapine-induced metabolic dysfunction

作　　者：徐萍[1] 饶顺曾[1] 李晨虎[1] 沈文龙[1] 

机构地区：[1]上海市徐汇区精神卫生中心,200232

出　　处：《四川精神卫生》2011年第2期80-82,共3页Sichuan Mental Health

基　　金：上海市徐汇区卫生局科研基金(编号SHXH20070301)

摘　　要：目的探讨行为干预治疗氯氮平所致体质量增加及糖、脂代谢紊乱的临床疗效。方法对口服氯氮平的235例精神分裂症患者随机分为行为干预组103例和对照组132例,行为干预组患者给予生活方式干预,治疗观察期限为6个月。所有患者于入组时及治疗6个月末测定体质量指数(BMI)、腰臀比率(WHR)、血压、总胆固醇(TC)、三酰甘油(TG)、空腹血糖(FBG),并进行比较。结果基线两组患者临床和实验室检查各指标间差异均无统计学意义(P>0.05)。干预6月后,行为干预组的BMI、腰围、空腹血糖、TC及收缩压与对照组比较差异均有统计学意义(P<0.05)。结论行为干预可改善氯氮平所致的体质量增加及糖、脂代谢异常。Objective To explore the clinical effects of behavioral intervention on bodyweight（BW）,glucose or lipid metabolic disorders induced by clozapine.Methods Two hundred and thirty five schizophrenic patients treated with clozapine were randomized into behavioral intervention group（n=103）and control group（n=132）.Behavioral intervention group was given lifestyle intervention,and treatment and observation lasted 6 months.Body mass index（BMT）and waist circumference（WC）,blood pressure（BP）,total cholesterol（TC）,triglycerol（TG）,fasting blood glucose（FBG）were measured at baseline and month 6.Results No significant changes were noted in all indexes of both groups at baseline（P〉0.05）.At the end of month 6,BMI,WC,FBG,TC and systolic blood pressure in behavioral intervention group were significantly different from those of control group（P〉0.05）.Conclusion Behavioral intervention is of relatively good effects in treatment of BW increase and glucose or lipidmetabolic diaorders induced by clozapine.

关 键 词：氯氮平 行为干预 代谢紊乱 

分 类 号：R749.053[医药卫生—神经病学与精神病学]