喹硫平治疗老年抑郁症的对照研究  

A control study of quetiapine in the treatment of elderly depression

作　　者：夏仲[1] 汪正华[1] 张军[1] 宋传福[1] 

机构地区：[1]安徽省芜湖市第四人民医院,241002

出　　处：《四川精神卫生》2011年第2期95-97,共3页Sichuan Mental Health

摘　　要：目的探讨喹硫平治疗老年抑郁症的疗效和安全性。方法将60例符合CCMD-3诊断标准的老年抑郁症患者随机分为二组,分别使用喹硫平和帕罗西汀治疗,疗程8周。用汉密尔顿抑郁量表(HAMD)、临床疗效总量表(CGI-SI)评定疗效,以治疗中出现的症状量表(TESS)评定不良反应。结果治疗8周末,两组的HAMD、CGI-SI评分差异无统计学意义(P均>0.05),两组的缓解率分别为63.3%和66.7%,疗效差异无统计学意义(P>0.05)。喹硫平组嗜睡和口干多见,而帕罗西汀组恶心、呕吐较多。结论喹硫平治疗老年抑郁症疗效与帕罗西汀相当,不良反应以嗜睡和口干多见,但恶心、呕吐较少。Objective To detect the efficacy and safety quetiapine and paroxetine in treatment elderly depression.Methods 60 patients with elderly depression who met CCMD-3 creatia were randomly assigned to two groups treated with quetiapine and paroxetine for 8 weeks.Hamilton depression scale（HAMD）and clinical global impression（CGI-SI）were used to evaluate the efficacy,and treatment emergent symptoms scale（TESS）were applied to evaluate side-effect of drugs.Results After 8 weeks treatment,there were no significant differences in the score of HAMD and CGI-SI between two groups（P〉0.05）.The total effective rates of quetiapine and paroxetine were 63.3%and 66.7%respectively,without any statistically significant difference between groups（P〉0.05）.Patients in quetiapine group had more drowsiness and dry mouth,yet patients in paroxetine had more nansea and vomiting.Conclusion Quetiapine and paroxetine were almost the same in efficacy in the treatment elderly depression.In terms of clinical manifestation,there are differences between male and female elderly depression.Patients in quetiapine group had more drowsiness and dry mouth,but had less nausea and vomiting.

关 键 词：抑郁症 老年人 喹硫平 帕罗西汀 

分 类 号：R749.4[医药卫生—神经病学与精神病学] R749.053[医药卫生—临床医学]