补肾益气活血中药治疗胎儿宫内生长迟缓的临床研究  

Clinical Study on Effect of Chinese Herbal Medicine for Supplementing Kidney and Qi and Activating Blood Circulation in Treating Intrauterine Growth Retardation of Fetus

作　　者：黄光英[1,2] 舒益民 叶望云[1,2] 原本旭[1,2] 乔福元[1,2] 

机构地区：[1]同济医科大学中西医结合研究所 [2]同济医科大学附属同济医院妇产科

出　　处：《中国中西医结合杂志》1999年第8期466-469,共4页Chinese Journal of Integrated Traditional and Western Medicine

基　　金：国家中医药管理局资助

摘　　要：目的：观察补肾益气活血中药治疗胎儿宫内生长迟缓（ＩＵＧＲ）的临床疗效，探讨其可能的作用机理。方法：将５５例胎儿宫内生长迟缓孕妇分为两组，用补肾益气活血中药（中药组）治疗３０例，并与用氨基酸治疗（氨基酸组）２５例进行比较。结果：中药组新生儿出生体重显著高于氨基酸组。中药组母体宫高、腹围以及胎儿生长参数，包括双顶径、头围、腹围、股骨长的增长均较氨基酸组快。治疗后中药组孕妇血清雌三醇、胎盘泌乳素接近于正常组，氨基酸组与正常组有明显差异。胎儿脐静脉血浆必需氨基酸浓度中药组较ＩＵＧＲ未治疗组明显改善，氨基酸组改变不及中药组；未发现补肾益气活血中药对母儿有明显不良反应。结论：补肾益气活血中药具有改善胎盘功能，促进胎盘转运氨基酸的作用。Objective: To explore the therapeutic effect and its possible mechanism on using Chinese herbal medicine (CHM) for supplementing Kidney and Qi, and activating blood circulation in treating intrauterine growth retardation of fetus (IUGR). Methods: Fifty five cases of IUGR were observed, 30 of them were treated with CHM and 25 treated with amino acid for control. Results: The neonatal birth weight in the CHM group was markedly greater than that in the control group. Not only the maternal fundal height and abdominal circumference, but also the fetal growth parameters, including biparietal diameter, head circumference, abdominal circumference, femur length in the CHM group increased much faster than those in the control group. After CHM treatment, the maternal serum levels of estriol (E 3) and human placental lactogen (hPL) were close to the normal pregnancy group, but the levels in the control group were significantly different from the normal range. The umbilical venous plasma concentration of essential amino acids was markedly improved after treatment, however, the improvement in the CHM group was more significant than that in the control group. No adverse effect of CHM was found both in mother and fetus. Conclusion: CHM for supplementing Kidney and Qi, and activating blood circulation was more effective in the improvement of placental function and amino acid transportation than those of amino acid.

关 键 词：IUGR 中医药疗法 胎盘功能 氨基酸 

分 类 号：R271.945.6[医药卫生—中西医结合]