癌灵一号治疗急性早幼粒细胞白血病62例  

Ailing No. I in Treating 62 Cases of Acute Promyelocytic Leukemia

作　　者：胡晓梅[1,2] 马玲[1,2] 胡乃平 王忠芬[1,2] 杨留 李柳[1,2] 王展翔 王洪志[1,2] 王楠 刘驰[1,2] 刘锋 杨经敏[1,2] 麻柔 

机构地区：[1]中国中医研究院西苑医院血液科 [2]全国中医血液病专科中心

出　　处：《中国中西医结合杂志》1999年第8期473-476,共4页Chinese Journal of Integrated Traditional and Western Medicine

摘　　要：目的：进一步了解癌灵一号治疗急性早幼粒细胞白血病（ＡＰＬ）的疗效、作用机制及毒副反应。方法：运用癌灵一号作诱导及巩固治疗６２例ＡＰＬ，观察其完全缓解（ＣＲ）率，治疗前后临床症状、外周血象、骨髓象、脏器功能及免疫指标等的变化。结果：诱导缓解治疗３１例，取得ＣＲ２７例，ＣＲ率为８７１％；巩固治疗３１例，持续缓解时间最长为３７个月，有７例在１个月～２年内复发。诱导治疗１周后ＷＢＣ显著升高，４周后明显下降；巩固治疗１周后ＷＢＣ开始下降，４周后呈回升趋势。Ｈｂ变化不大。Ｐｌｔ治疗后较治疗前显著升高。对骨髓（ＢＭ）抑制不明显。治疗前后Ｔ细胞亚群及免疫球蛋白测定值无明显变化。临床毒副反应表现多端，以消化道反应为突出，对肝脏有一定的损害。结论：癌灵一号疗效好，缓解率高，疗效持久。Objective: To obtain further knowledge on the effect, mechanism and toxic side effect of Ailing No. I (AL), a preparation of As 2O 3, in treating acute promyelocytic leukemia (APL). Methods: AL was used in induction and consolidation treatment of 62 cases of APL, the effect of treatment and the changes of clinical symptoms, peripheral blood and bone marrow pictures, T lymphocyte subset, and immunofunctions of patients after treatment were observed. Results: Twenty seven cases out of the 31 patients who received induction treatment got complete remission (CR), the CR rate being 87.1%. Of the 31 cases who received consolidation treatment, the longest remission period was 37 months, and 7 cases relapsed within one month to 2 years. Peripheral white blood cell count raised after one week but lowered after 4 weeks of induction treatment, but in receiving consolidation treatment, it started to lower after one week and raised after 4 weeks of treatment. No obvious change on hemoglobin level was observed. Platelet count significantly increased after treatment. The treatment showed no obvious inhibiton on bone marrow. The T lymphocyte subsets and immunoglobulin level were changed insignificantly after treatment. Various side effects were shown clinically, particularly those digestive tract involved symptoms were prominent, and liver damage was shown in a certain degree. Conclusion: AL has good and protracted effect in treating APL with high CR rate, the mechanism may be related with its cytotoxicity and action of differentiation induction.

关 键 词：癌灵一号 白血病 髓细胞性 急性 治疗 

分 类 号：R733.710.5[医药卫生—肿瘤]