中医药治疗干眼症疗效的Meta分析  

Treatment of dry eye with traditional Chinese medicine:A Meta-analysis

作　　者：王芬[1] 彭清华[1] 姚小磊[1] 王方[1] 

机构地区：[1]湖南中医药大学第一附属医院眼科,湖南省长沙市410007

出　　处：《眼科新进展》2011年第5期434-437,456,共5页Recent Advances in Ophthalmology

基　　金：国家自然科学基金面上资助项目(编号:30772824)~~

摘　　要：目的运用Meta分析法系统评价中医药治疗干眼症的疗效。方法按Cochrane系统评价方法 ,计算机检索Cochranelibrary、Pubmed、CBM(1997-2009)、CNKI(1999-2010)、VIP(1999-2010)数据库,纳入中医药治疗干眼症的随机及半随机对照试验,并按Cochrane协作网推荐的方法进行质量评价、资料提取和Meta分析。结果共纳入18个随机对照研究文献,包括1728例患者。Meta分析结果显示:BUT的测定:5个研究的治疗组在疗程结束后的BUT延长,差异有统计学意义[WMD=1.47,95%CI(1.02,1.92)]。泪液流量测定:4个研究的治疗组在疗程结束后的泪液流量测定明显增加,差异有统计学意义[WMD=1.95,95%CI(1.23,2.68)]。总体疗效判定:治疗组在疗程结束后总体疗效明显好转,差异有统计学意义[OR=4.16,95%CI(3.18,5.43)]。结论现有研究显示,相对于单纯运用西药治疗干眼症,中医药在治疗干眼症方面能延长患者BUT、增加其泪液流量、能更有效地改善患者的自觉症状,总体疗效上起到明显的效果,但限于目前研究中医药治疗干眼症的文献报道质量低、数目有限,仍然需要大样本、多中心随机对照试验,以进一步证实中医药治疗干眼症的优越性。Objective To systematically evaluate the efficacy of traditional Chinese medicine（TCM）in the treatment of dry eye by Meta-analysis.Methods The electronic bibliographic databases were searched,including Cochrane library,Pubmed,CBM（from 1997 to 2009）,VIP（from 1999 to 2010）and CNKI（from 1999 to 2010）,the randomized controlled trials of TCM treatment compared with Western medicine treatment of the dry eye were assembled.Data were extracted and evaluated by two reviewers independently with a designed extraction formation by Meta-analysis based on the Cochrane net suggestion.Results A total of 18 randomized controlled trials involving 1 728 patients were included.After the treatment,the results of Meta-analyses showed that the TCM treatment significantly increased the BUT in the treatment group of five studies[WMD=1.47,95%CI（1.02,1.92）],TCM treatment significantly increased the Schirmer I test（SIt）in the treatment group of four studies[WMD=1.95,95%CI（1.23,2.68）],TCM treatment could significantly improve the overall efficacy[OR=4.16,95%CI（3.18,5.43）].Conclusions The available studies show that compared with Western medicine,TCM treatment for dry eye can increase the BUT and the SIt,also improve the overall efficacy.But owing to the limited studies and few number of TCM treatment for dry eye,the large sample and multicenter randomized controlled trial is still needed to verify the superiority of TCM for dry eye.

关 键 词：中医药治疗 干眼症 随机对照试验 META分析 

分 类 号：R777.2[医药卫生—眼科]