低浓度磷酸根对碳酸羟基磷灰石溶解度的影响  

The effect of low concentration phosphate on the solubility of carbonated hydroxyaptite

作　　者：刘泉[1,2] 陈卓凡[1,2] 

机构地区：[1]中山大学光华口腔医学院.附属口腔医院 [2]中山大学口腔医学研究所,广东广州510055

出　　处：《临床口腔医学杂志》2011年第5期278-281,共4页Journal of Clinical Stomatology

基　　金：国家自然科学基金面上项目(30973355)

摘　　要：目的:测定碳酸羟基磷灰石(CHA)在含低浓度磷酸根的检测溶液中的溶解度,探讨磷酸根对CHA体外溶解过程的影响。方法:采用固体滴定法检测CHA在(37.0±0.1)℃恒温下、含0.5mmol/L磷酸根的0.1mol/LKCl溶液中的溶解过程并绘制溶解度等温曲线。采用扫描电镜(SEM)、X射线衍射分析(XRD)及能谱分析(EDX)检测CHA的理化性能。结果:在KCl溶液中,CHA的溶解度高于羟基磷灰石,低于无机牛骨;在0.5mmol/L磷酸根背景溶液中,CHA的溶解度略有升高。结论:CHA的溶解不遵循经典的热动力学理论规律,其溶解度与pH值相关。低浓度磷酸根可促进CHA溶解。Objective： To determine the solubility of carbonated hydroxyapatite （CHA） in aqueous KC1 （0.1 tool / L） and / or KH2PO4 （0.5 mmol / ID atl （37.0 ＋ 0.1）℃ with pH 3.5～5.0. Method： The titration end-point of the solid CHA used was monitored by a low-angle laser-scattering system. Total added solid and the solution pH value were used to identify the solubility of CHA in aqueous KC1 （0.1 mol / L） and / or KH2PO4 （0.5 mmol / L）. The solid titrant was characterized by scanning electronic microscopy （SEM）, X-ray diffraction （XRD）, energy dispersive X-ray spectroscopy （EDX）. Result： The solubility of CHA in 0.1 mol / L aqueous KC1 was higher than that of stoichiometric hydroxyapatite, but lower than that of bovine bone. A slightly increase was observed with 0.5 mmoI / L KH2PO4. Conclusion： The dissolution of CHA does not fol- low the classic thermodynamic theory. Its solubility is related to the solution pH and could be increased by low concentration phosphate.

关 键 词：羟基磷灰石 溶解度 磷酸根 固体滴定 

分 类 号：R780.1[医药卫生—口腔医学]