双侧肾上腺切除大鼠脑缺血后血脑屏障破坏的研究  

Blood brain barrier damaged in the cerebral ischemia rat after bilateral adrenalectomy

作　　者：任明[1,2] 朱克[1,2] 黄旭升 张风英[1,2] 刘洁晓 

机构地区：[1]第二军医大学附属长征医院神经内科 [2]解放军总医院神经内科

出　　处：《临床神经病学杂志》1999年第4期202-203,共2页Journal of Clinical Neurology

摘　　要：目的观察脑缺血时体内自身的糖皮质激素变化对血脑屏障（ＢＢＢ）的影响。方法采用线栓法造成脑缺血模型，用辣根过氧化物酶组织化学染色的方法，观察双侧肾上腺切除大鼠局灶脑缺血后血脑屏障的改变。结果双侧肾上腺切除后脑缺血组（Ａ组）大鼠ＢＢＢ破坏的范围为１０．１０１±１．４１１ｍｍ２；单纯脑缺血组（Ｂ组）大鼠ＢＢＢ破坏范围为６．１９１±１．０４５ｍｍ２，Ａ组大鼠ＢＢＢ破坏的范围大于Ｂ组大鼠ＢＢＢ破坏的范围（Ｐ＜０．０１）。结论脑缺血时体内自身的糖皮质激素升高对ＢＢＢ具有保护作用。Objective To observe the effect of increased glucocorticoid within circulation on blood brain barrier(BBB) in the cerebral ischemic rat after bilateral adrenalectomy.Methods Producing focal cerebral ischemia model using thread occlusion method in bilateral adrenalectomic rat, detecting the changes of BBB destroyed with horse radish peroxidase histochemical staining. Results The area of BBB damaged of group A was 10.101±1.411 mm 2(bilateral adrenalectomy plus cerebral ischemia).It was larger than that of group B( P <0.01),the area of BBB damaged in merely cerebral ischemia group was 6.191±1.045 mm 2. Conclusion During cerebral ischemia,the increased glucocorticoid might play a protective role on ischemic cerebral tissue through decreasing BBB permeability.

关 键 词：大鼠 肾上腺切除 脑缺血 血脑屏障 

分 类 号：R743.302[医药卫生—神经病学与精神病学]