动脉粥样硬化性血栓性脑梗塞患者血浆氧化修饰低密度脂蛋白含量的研究  

A study on concentration of plasma OX LDL in patients with atherosclerotic thrombotic cerebral infarction

作　　者：杜怡峰[1,2] 孙圣刚[1,2] 童萼塘[1,2] 刘红进 

机构地区：[1]同济医科大学附属协和医院神经内科 [2]青岛医学院附属医院神经内科

出　　处：《临床神经病学杂志》1999年第4期213-215,共3页Journal of Clinical Neurology

摘　　要：目的探讨氧化修饰低密度脂蛋白（ＯＸ－ＬＤＬ）与动脉粥样硬化性血栓性脑梗塞（ＡＴＣＩ）发生、发展的关系。方法应用酶联免疫吸附试验（ＥＬＩＳＡ）双抗夹心法检测了８３例ＡＴＣＩ患者血浆ＯＸ－ＬＤＬ含量变化。结果（１）ＡＴＣＩ组血浆ＯＸ－ＬＤＬ水平显著高于正常对照组（Ｐ＜０．０１）；血浆ＯＸ－ＬＤＬ水平变化与病程有关，但与梗塞部位无关。（２）ＡＴＣＩ患者血浆ＯＸ－ＬＤＬ水平与血糖、血胆固醇呈正相关。结论ＯＸ－ＬＤＬ可能参与了ＡＴＣＩ的发生和发展过程。Objective To explore the relationship between oxidized low density lipoprotein(OX LDL) and the pathogenesis of atherosclerotic thrombotic cerebral infarction (ATCI). Methods The changes of plasma OX LDL in 83 patients with ATCI were observed by an enzyme linked immunosorbent assay(ELISA). Results (1)The levels of plasma OX LDL in ATCI group were higher than those in the control ( P <0.01); and the change of plasma OX LDL ralated to the course, but it did not show any significant diffe rence between patients with the cerebral infarction of cortical artery territory and patients with the cerebral infarction of perforating artery territory. (2) The OX LDL concentrations had a positive correlation with blood sugar and cholesterol. Conclusion OX LDL might play a key role in the pathogenesis of ATCI.

关 键 词：动脉粥样硬化 脑梗塞 OX-LDL 

分 类 号：R743.330.2[医药卫生—神经病学与精神病学]