抗溃结复发方对UC模型大鼠结肠黏膜形态的影响  

Influence of Ulcerative Colitis Contra-relepse Prescription in Colon Tissue Pathological Change of Ulcerative Colitis Model in Rat

作　　者：安贺军[1] 王新月[2] 于玫[3] 沈静[3] 

机构地区：[1]解放军第306医院中医科,北京100101 [2]北京中医药大学东直门医院消化科,北京100700 [3]北京中医药大学,北京100029

出　　处：《辽宁中医药大学学报》2011年第6期24-26,共3页Journal of Liaoning University of Traditional Chinese Medicine

基　　金：国家自然科学基金资助项目(30572390)

摘　　要：目的:抗溃结复发方对UC模型大鼠结肠黏膜形态的影响。方法:用三硝基苯磺酸(TNBS)复制实验性大鼠UC模型,将其随机分为模型组、西药对照组、中药治疗组,并设正常对照组。结果:两治疗组急性期损伤减轻,但中药治疗组与西药组相比表现为重;中期、缓解期慢性炎性细胞浸润和腺体破坏减轻,中药治疗组修复加快优于西药组。结论:中西药物对局部黏膜均有抑制炎症反应和促进组织修复作用;在急性期西药抑制损伤方面优于中药,在中期和缓解期促进肉芽组织增生修复方面中药优于西药。Objective：To investigate the influence of ulcerative colitis contra-relepse prescription in colon tissue pathological change of ulcerative colitis model in rat.Methods：UC model of experimental rats were duplicated with TNBS and acute abscess of areolarandomly divided into model control group,western medicine group,the traditional Chinese medicine group,and normal control group.Results：Acute stage damage was lessend in two treatment groups.The appearance was more serious in the traditional Chinese medicine group than that in western medicine group.Tissue repair of the traditional Chinese medicine group was more accelerated in intermediate and catabasis stage.Conclusion：The study shows as the observation of the local colon mucosa,two kind of medines have the effects of inhibiting the injury and improving the plerosis of mucosa tissues.The effect emphasized on the different aspect.Restrain damage effection of western medicine is better than that of the traditional Chinese medicine in acute stage;but improving granulation tissue accrementition repair is more accelerated in the traditional Chinese medicine group in intermediate and catabasis stage.

关 键 词：溃疡性结肠炎 抗复发 结肠黏膜形态 

分 类 号：R574.62[医药卫生—消化系统]