2型糖尿病大鼠胰腺微区血液灌流量与空腹血糖的相关性研究  

Relationship of microcirculatory hemoperfusion in pancreas and fasting blood glucose of type 2 diabelie rats

作　　者：刘瑶[1] 李鸿燕[1] 周慧敏[1] 杨爱格[1] 张庆富[2] 

机构地区：[1]河北医科大学第一医院内分泌科,石家庄050031 [2]河北医科大学第一医院烧伤科,石家庄050031

出　　处：《国际内分泌代谢杂志》2011年第3期152-154,共3页International Journal of Endocrinology and Metabolism

基　　金：河北省科技攻关重大项目（07276103D）

摘　　要：目的 观察2型糖尿病大鼠胰头及胰体尾微区血液灌流量动态变化及其与空腹血糖的相关性.方法 Wistar 大鼠随机分为对照组（n=130）及实验组（n=150）,实验组给予高脂、高糖饮食及腹腔注射小剂量链脲佐菌素（30 ms/kg）复制2型糖尿病大鼠模型.分别于成模后0,4,8,12,16周每组随机选取20只大鼠,活体状态下测空腹血糖、胰头及胰体尾微区血液灌流量.结果 造模后,实验组大鼠空腹血糖逐步升高（P〈0.05）,各时点分别为（10.25±7.98）,（14.72±7.51）,（19.23±6.09）,（22.44±7.45）,（26.03±4.96）mmol/L;胰体尾部微区血液灌流量逐步升高（P〈0.05）,各时点分别为（2.46±0.90）,（2.79±1.34）,（3.15±1.24）,（3.76±0.99）,（4.28±0.23）V;各时点胰头微区血液灌流量与对照组相比无显著变化（P〉0.05）.胰体尾部微区血液灌流量与空腹血糖呈正相关（r=0.3786,P〈0.05）.结论 2型糖尿病大鼠空腹血糖升高可引起胰体尾微区血液灌流量增加.Objective To observe the dynamic change of microcirculatory hemoperfusion in pancreatic head,body and tail of type 2 diabetic rats and its relationship with fasting blood glucose.Method All Wistar rats were randomly divided into control group（n=130）and experimental group（n=150）.The rat model of type 2 diabetes mellitus was established by high-fat,high-sugar feeding combined with low-dose streptozotocin（30 mg/kg）.At the 0,4,8,12,16 weeks after the occurrence of diabetes,twenty rats were picked up randomly and respectively from two groups,and microcirculatory hemoperfusion in pancreatic head,body and tail and fasting blood slucose were measured in vivo.Results At the 0,4,8,12,16 weeks after the occurrence of diabetes,fasting blood glucose in experimental group were（10.25±7.98）,（14.72±7.51）,（19.23±6.09）,（22.44±7.45）,（26.03±4.96）mmol/L respectively,while microcirculatory hemoperfusion in pancreatic body and tail were（2.46±0.90）,（2.79±1.34）,（3.15 ±1.24）,（3.76±0.99）,（4.28±0.23）V respectively.They both increased progressively（P〈0.05）.No significant changes were found in pancreatic head compared with control group（P〉0.05）. Microcirculatory hemoperfusion in pancreatic body and tail was positively associated with fasting blood glucose（r=0.3786,P〈0.05）.Conclusion Microcirculatory hemoperfusion in pancreatic body and tail increased with the increase of fasting blood glu cose in type 2 diabetic rats.

关 键 词：2型糖尿病 大鼠 血液灌流量 空腹血糖 

分 类 号：R151.2[医药卫生—营养与食品卫生学]