心脏ECT展开图评价异舒吉和硝酸甘油抗心肌缺血作用  

Myocardiun ECT unfold map is applied to evaluate the effcet of anti myocaridum ischemia of Isoket and Nitroglycerin

作　　者：孟繁波[1] 杨平[1] 赵林阳[1] 张木兰[1] 徐文贵[2] 耿威[3] 

机构地区：[1]白求恩医科大学第三临床学院心血管内科,长春130021 [2]白求恩医科大学第三临床学院核医学科 [3]吉林市中心医院干部病房

出　　处：《中国老年学杂志》1999年第5期268-269,共2页Chinese Journal of Gerontology

基　　金：吉林省卫生厅 1996 年度青年基金

摘　　要：目的　评价比较 ２ 种药物异舒吉和硝酸甘油抗心肌缺血作用。方法　利用９９ ｍ Ｔｃ Ｍ Ｉ Ｂ Ｉ灌注断层显象展开图比较药物治疗前后左室缺血面积的改善情况，用面积的改善反映药物的抗心肌缺血作用。结果　异舒吉治疗前后缺血心肌面积分别为３２５９７± ６２９５ ｃｍ ２ 、２８６７３ ±３１３１ ｃｍ ２， 治 疗前 后缺血 面积 与左 室面 积的 百分 比分别 为 １７２５４％ ±５６１４％ 、１５４０１％ ±２７８０％ ；硝酸甘油治疗前后缺血面积分别为 ３２１２６ ±５４７８ ｃｍ ２ 、２９７０２±２９８２ ｃｍ ２， 缺血面积与左室面积 的百分比分别为１６９８９％ ±５６１４％ 、１５９２３％ ±２７８０％ （ Ｐ＜ ００５）。治疗前后，异舒吉组的缺血面积改善程度与硝酸甘油组相比无差异（ Ｐ ＞００５）。结论　异舒吉和硝酸甘油均有抗心肌缺血作用，临床医生需要注意“Threshold and frequency of angina pectoris and variation of electrocardiogram were used as criterion to evaluate the effects of anti myocardium ischemia drug. 99m Tc MIBI myocardial perfusion imaging unfold map may be applied to measure the ischemic myocardium area quantitativly. 23 patients who used Isoket and compared with 10 patients treated with nitroglycerin. Ischemic area and the whole left ventricular area examined by radionuclide myocardial imaging before and after two different drugs were administrated, and the ratio of ischemic area and left ventricular area were decreased, with the ratio of ischemic myocaridum area of the Isoket group improved more significant than the nitroglycerin group. Conclusions although isokectis better but attention of cost effcetiveness analysis must be considered.

关 键 词：异舒吉 硝酸甘油 ECT 展开图 成本-效果分析 

分 类 号：R972.3[医药卫生—药品]