红细胞TF抗原用于老年恶性肿瘤病人的特异性主动免疫治疗  

Using erythrocyte Thomsen Fridenreich(TF) antigen to achieve active specific immunotherapy on elderly cancer patients

作　　者：宋东[1] 乔伟嵩[1] 郭夯[1] 刘国津[1] 

机构地区：[1]白求恩医科大学第一临床学院,长春130021

出　　处：《中国老年学杂志》1999年第5期278-279,共2页Chinese Journal of Gerontology

摘　　要：目的　使用一种癌症疫苗探讨其对老年癌症患者的疗效。方法　用神经氨酸酶处理红细胞，使其表面隐匿的 Ｔ Ｆ抗原暴露，作为一种癌症疫苗对癌症患者进行特异性主动免疫治疗。结果　所有病人在治疗后其行为状态明显改善（ Ｐ＜ ０００１）；淋巴细胞转化能力增强，白细胞介素Ⅱ活性增加（均 Ｐ＜ ００１），这种改变在晚期肿瘤病人（ Ｔ Ｎ Ｍ 分期为Ⅲ、Ⅳ期）表现得尤为显著。结论　用自身红细胞中提取的 Ｔ Ｆ 抗原制成的癌症疫苗能控制肿瘤生长，改善老年癌症病人的行为状态，提高生活质量。Objective A sort of carcinoma vaccine was used on elderly cancer patients and the therapeutic resutts were evaluated.Methods Using neuraminidase to process the erythrocyte, so as to expose the cryptic TF Ag on the cell surface. The processed erythrocyte was then transferred back to cancer patients to achieve an active specific immunotherapy.Results After the treatment, the performance status of all patients ameliorated significantly (P<0 001) . All patients showed significant enhancement of lymphocytic proliferation ability and elevation of interleukin 2 activity(both P<0 01) . The tendency is even more obvious in patients with metastasis(TNM stages were 3 or 4).Conclusions The autologous erythrocyte TF Ag carcinoma vaccine can suppress the growth of cancer, ameliorate the performance status of elderly cancer patient and improve their life quality.

关 键 词：癌症疫苗 特异性 主动免疫治疗 红细胞TF抗原 

分 类 号：R730.51[医药卫生—肿瘤]