频域相干光断层扫描对糖尿病黄斑区厚度的应用研究  

Analysis of macular thickness in diabetic patients by optical coherence tomography

作　　者：祃红燕[1] 钱勇[1] 段文静[1] 刘菊[1] 卢颖[1] 

机构地区：[1]华北电网有限公司北京电力医院眼科,北京100073

出　　处：《临床眼科杂志》2011年第2期101-103,共3页Journal of Clinical Ophthalmology

摘　　要：目的利用频域相干光断层扫描(OCT)测量并分析糖尿病(DM)患者的黄斑区视网膜厚度。方法 DM组90例(90只眼),并分为分无糖尿病视网膜病变(NDR)、非增殖期(NPDR)及增殖期(PDR)病变3组,每组各30例(30只眼),正常对照组30例(30只眼)。分别行最佳矫正视力(BCVA)、裂隙灯、眼底彩照、荧光素眼底血管造影(FFA)和OCT检查。采用OCT观察DM患者黄斑区图像特征,应用黄斑地形图分析软件测量黄斑部9个分区的视网膜厚度,并进行DM患者和正常人黄斑部厚度之间的相关性分析。结果直径1 mm的中央区(CSF)视网膜平均厚度分别为:NDR组(225.8±18.0)μm、NPDR组(246.8±34.2)μm、PDR组(323.5±92.2)μm、正常对照组(224.8±15.9)μm。NDR与正常对照组黄斑区厚度之间差异不具有统计学意义(P>0.05),NPDR、PDR与对照组之间的差异具有统计学意义(P<0.05)。结论 OCT能定量定性地观察DM患者黄斑区的变化,为糖尿病黄斑病变提供可靠的检测手段。Objective Investigate and analyze the macular thickness in diabetic patients by optical coherence tomography（OCT） measurements.Methods There were 30 eyes（30 cases） in normal control group,and 90 eyes（30 cases） in diabetic group.The diabetic patients were divided into three groups： non-diabetic retinopathy（NDR）,non-proliferative diabetic retinopathy（NPDR） and proliferative diabetic retinopathy（PDR）.We observed the different tomographic features of diabetic macula and measured macular thickness.For each eye,nine different sectors were analyzed（central subfield,four parafoveal sectors,and four extrafoveal sectors）.All the people had undergone examination of BCVA,slit lamp,ocular fundus,FFA and OCT.Results he average retinal thickness at central subfield（CSF） with 1 mm diameter respectively were NDR Group（225.8±18.0）μm,NPDR Group（246.8±34.2）μm,PDR Group（323.5±92.2）μm,Contral Group（224.8±15.9）μm.There were statistically significant differences in CSF among NPDR group,PDR group and the control eyes（P 0.05）.But no significant difference between NDR group and the control eyes.Conclusion OCT can detect macular thickness and structural changes in eyes with DM.It is a useful tool to diagnose and monitor diabetic maculopathy.

关 键 词：相干光断层扫描 视网膜厚度 糖尿病黄斑病变 糖尿病性黄斑水肿 

分 类 号：R774.5[医药卫生—眼科]