N-糖基化修饰蛋白gp73与肝硬化患者Child-Pugh的关系  

Relationship between N-glycosylated protein gp73 and Child-Pugh stage in cirrhotic patients

作　　者：黄玉波[1] 李鑫[1] 乔雍[1] 常路丝[1] 肖凡[1] 魏红莲[2] 张仁雯[3] 成军[1] 魏红山[1] 

机构地区：[1]首都医科大学附属北京地坛医院,北京100015 [2]首都医科大学附属同仁医医院 [3]北京大学医学部研究生院

出　　处：《胃肠病学和肝病学杂志》2011年第4期335-337,共3页Chinese Journal of Gastroenterology and Hepatology

基　　金：国家自然科学基金(No.30671875;No.30872243);北京市优秀人才培养专项经费资助项目(2009D003015000001)

摘　　要：目的评价N-糖基化修饰蛋白gp73的血清水平与肝硬化患者Child-Pugh之间的关系及其可能的临床意义。方法所观察的患者均为2009年1月~2010年10月在北京地坛医院门诊及住院肝硬化患者,所有患者均为HBsAg阳性。观察患者共610例,其中男性患者448例,年龄17~82岁,平均48岁;女性患者162例,年龄18~76岁,平均55岁。入组肝硬化患者的Child-Pugh分级主要依据血清白蛋白、总胆红素、凝血酶原活动度、腹水及肝性脑病评价等5项指标。血清gp73浓度采用ELISA法检测。结果伴随肝功能衰退,血清gp73水平也相应升高。血清gp73水平Child-Pugh为C级的患者（255.78 ng/mL±100.89 ng/mL）显著高于B级（203.30 ng/mL±99.15 ng/mL）和A级的患者（125.28 ng/mL±67.05 ng/mL）。血清gp73与白蛋白之间呈显著负相关（r=-0.52,P〈0.0001）。结论 HBV感染肝硬化患者血清gp73水平随肝功能恶化而升高。Objective To evaluate the relationship between serum concentration of gp73 and Child-Pugh stage in cirrhotic patients.Methods All subjects with HBsAg-positive were diagnosed as cirrhotic patients in Beijing Ditan Hospital,from January 2009 to October 2010.Total 610 subjects were included.The Child-Pugh score was based on albumin,total bilirubin,prothrombin activity,ascites and hepatic encephalopathy.Serum concentration of gp73 was determined by ELISA method.Results The serum concentration of gp73 in patients with C stage（255.78 ng/mL±100.89 ng/mL） was higher than that in patients with B stage（203.30 ng/mL ± 99.15 ng/mL） and A stage（125.28 ng/mL ± 67.05 ng/mL）.The serum concentration of gp73 was negatively correlated with serum albumin（r=-0.52,P0.0001）.Conclusion Serum level of gp73 was correlated with Child-Pugh stage in cirrhotic patients.

关 键 词：肝硬化 高尔基体糖蛋白73(gp73) 肝功能 CHILD-PUGH分级 

分 类 号：R575.2[医药卫生—消化系统]