腺苷蛋氨酸治疗药物性肝损伤效果的系统评价  

Systematic evaluation on the efficacy of ademetionine in patients with drug-induced liver injury

作　　者：赵攀[1] 段光锋[2] 杜丽[1] 徐东平[1] 唐彦[1] 韩玉坤[1] 

机构地区：[1]解放军第302医院肝衰竭诊疗与研究中心病毒性肝炎研究室,北京100039 [2]第二军医大学卫勤系信息室

出　　处：《胃肠病学和肝病学杂志》2011年第4期341-344,共4页Chinese Journal of Gastroenterology and Hepatology

摘　　要：目的系统评价腺苷蛋氨酸治疗药物性肝损伤的效果。方法检索2010年9月以前在CBMdisk、CNKI全文数据库、万方中文期刊全文数据库、维普中文期刊全文数据库公开发表的有关腺苷蛋氨酸治疗药物性肝损伤的随机对照临床研究。采用χ2检验分析研究间的异质性,以加权平均数为疗效分析统计量进行合并分析并绘制森林图。疗效判定指标包括血清总胆红素、ALT和γ-谷氨酰转肽酶。结果共检索到126篇文献,经筛选和评价后最终纳入4篇文献。Meta分析结果显示,腺苷蛋氨酸组(治疗组)血清总胆红素(P=0.003)和ALT(P=0.0002)的均数低于对照组,差异有统计学意义;但两组γ-谷氨酰转肽酶的均数差异无统计学意义(P=0.07)。结论腺苷蛋氨酸可显著降低药物性肝损伤患者的血清总胆红素和ALT,但对γ-谷氨酰转肽酶的影响不显著。Objective To evaluate the efficacy of ademetionine in patients with drug-induced liver injury.Methods Articles（randomized controlled clinical trials） published in CBMdisk,CNKI（National Knowledge Infrastructure）,Wangfang database and Vip database before September-2010 about the efficacy of ademetionine in patients with drug-induced liver injury were searched.Heterogeneity was examined by Chi-square test,the weighted mean difference was calculated and forest-graph was drawn.The evaluated index contained serum total bilirubin（TBil）,ALT and γ-glutamyl transpeptidase（GGT/γ-GT）.Results In 126 articles,4 articles were selected out,which fitted well the study.Meta analysis showed that the means of serum TBil（P=0.003） and ALT（P=0.0002） were statistically different between ademetionine group（treatment group） and control group.However,GGT/γ-GT had no statistic significance between the two groups（P=0.07）.Conclusion Ademetionine decreased serum TBil and ALT significantly,but it had little influence on GGT/γ-GT.

关 键 词：腺苷蛋氨酸 药物性肝损伤 META分析 

分 类 号：R575[医药卫生—消化系统]