Jitter测定在评价重症肌无力病情严重程度中的意义  

Significance of Jitter Measurement in Evaluating the Severity of Myasthenia Gravis

作　　者：陈向军[1] 程源深[1] 

机构地区：[1]浙江医科大学附属第二医院神经科

出　　处：《中国临床神经科学》1999年第3期147-150,共4页Chinese Journal of Clinical Neurosciences

摘　　要：目的:探讨Jitter值对判断重症肌无力(MG)病情及预后的意义。方法:运用单纤维肌电图(SFEMG)技术对49例不同病情、病型及治疗的MG患者进行Jitter值测定,同时测定每一例的临床绝对评分。结果:(1)临床绝对评分、Jitter各指标与病型均有关,且Jitter各指标对区分眼型(Ⅰ)和全身型(Ⅱ)有所帮助;(2)MG患者个体MCI)均值、＞55μs电位对百分比及阻滞电位对百分比与临床绝对评分之间呈显著负相关(P＜0.001),而正常电位对百分比与临床绝对评分之间存在显著正相关(P＜0.001);(3)病程与Jitter各指标之间均无相关性(P＞0.05);(4)短期随访经激素治疗或手术治疗后乙酰胆碱受体抗体(AChRab)有转阴趋势,而SFEMG和低频重复电刺激检查结果转阴趋势不明显。结论:Jitter值测定是一项评价重症肌无力病情严重程度较为客观、准确的技术。Aim: To study the significance of Jitter measurement in evaluating the severity of MG. Methods : We have measured Jitters in 49 MG patients with different severity, type and treatment, and every patient was scored by Clinical Absolute Score (CAS) at the same time. Results: (1)CAS and three parameters of Jitter were correlated with disease type(P<0. 05), Jitter parameters were of some value to distinguish ocular MG( Ⅰ ) and generalized MG(Ⅱ ); (2)mean MCD, the percentage of pairs more than 55μs and blocking pairs had significant negative correlation with CAS (P<0. 001), the percentage of normal pairs had significant positive correlation with CAS (P<0. 001); (3) there was no significant difference between disease course and mean MCD, three parameters of Jitter (P>0. 05) ; (4)during the short period of follow-up, AChRab tended to be negative more predominantly than two kinds of electrophysiologic methods. Conclusion: Jitter measurement was a more objective and accurate technique to evaluate the severity of MG.

关 键 词：重症肌无力 单纤维肌电图 Jitter测定 

分 类 号：R746.104[医药卫生—神经病学与精神病学]