卵巢癌患者围手术期血清胰岛素样生长因子-2和胰岛素样生长因子结合蛋白-3检测的临床意义  

Clinical significance of serum IGF-2 and IGFBP-3 in perioperative period patients with ovarian cancer

作　　者：王荣珍 陆颜燕 田永华 蒙开熠 

机构地区：[1]解放军第三0三医院妇产科,南宁530021

出　　处：《中国医师杂志》2011年第4期458-460,共3页Journal of Chinese Physician

基　　金：基金项目：303医院科研基金项目

摘　　要：目的探讨卵巢癌患者围手术期血清胰岛素样生长因子-2（IGF-2）和胰岛素样生长因子结合蛋白-3（IGFBP-3）的变化及其临床意义。方法采用酶联吸附免疫法（ELISA）测定40例健康对照组及82例卵巢癌患者手术前后血清IGF-2和IGFBP-3的水平，观察健康对照组与卵巢癌患者手术前后血清IGF-2和IGFBP-3的水平变化，分析卵巢癌病人血清IGF-2和IGFBP-3水平与临床特征的关系。结果卵巢癌手术前病人血清IGF．2及IGFBP-3水平明高于正常对照组[（101．5±22．2）ne／ml，（49．3±15．6）ng／mlvs（69．6±17．7）ng／ml，（23．9±11．3）rig／ml，t=3．74，2．85，P〈0．05]；卵巢癌病人有淋巴结转移者血清IGF-2水平[（109．4±20．0）rig／m1]高于无淋巴结转移者[（89．9±16．6）ng／frll]（t’=4．10，P〈0．05），而IGFBP-3水平[（39．8±11．1）ng／m1]低于无淋巴结转移者[（55．8±19．2）ng／m1]（t’=4．49，P〈0．05）；肿瘤临床TNM分期中III—IV期者血清IGF-2水平[（107．5±24．0）ng／m1]高于I—II期者[（91．6±17．7）ng／m1]（t=2．83，P〈0．05），而IGFBP-3水平[（41．7±16．9）ng／m1]低于I～II期者[（56．9±19．1）ng／m1]（t=2．37，P〈0．05），根治性手术组病人术后IGF-2及ICFBP-3水平明显低于术前[（103．4±27．2）ng／ml，（50．2±16．6）ng／mlvs（86．6±12．3）ng／IIll，（41．1±17．1）ng／ml，f=2．48，3．32，P〈0．05]，姑息性手术组病人术前术后血清IGF-2及IGFBP．3水平无明显变化（P〉0．05）。根治性手术组病人术后血清IGF-2及IGFBP-3水平低于姑息性手术组术后[（86．6±12．3）ng／ml，（41．1±17．1）ng／mlvs（103．2±26．0）rig／ml，（45．3±14．9）ng／ml，t’=3．46，t=2．67，P〈0．05]。结论卵巢癌患者血清IGF-2和IGFBP-3的水平与肿瘤的浸润转移、临床分期及根治性手术有关，动态检测卵巢癌患者血清IGF-2和IGFBP-3的变化Objective To investigate the changes of serum insulin-like growth factor-2 （IGF-2） and insulin-link growth factor binding protein-3 （ IGFBP-3 ） in the patients with ovarian cancer before and after operation, and evaluate their clinical significance. Methods The contents of serum IGF-2 and IGFBP 3 in 82 patients with ovarian cancer were detected by ELISA before and after operation and compared with that in health controls. Results The contents of IGF-2 in the patients before operation were significantly higher than that in control group[ （ lO1.5 4± 22. 2 ） ng/ml, （ 49. 3 4± 15. 6） ng/ml vs （ 69. 6± 17.7 ） ng/ml, （23.9 ±11.3 ） ng/ml, t = 3.74,2. 85, P 〈 0. 05 ]. The contents of IGFBP-3 [ （ 39. 8 ± 11.1 ） ng/ml ] in the patients before operation were signifieantly lower than that in control group [ （55. 8 ± 19. 2 ）ng/ml] （ t＇ = 4. 49, P 〈 O. 05 ）. There was signifieant eorrelation between the eontents with lymph node metastasis and elin- ieal stage[ （107.5 ±24.0）ng/nd, （41.7 ± 16. 9） ng/ml vs （91.6 ± 17.7）ng/ml, （56.9 ± 19. 1 ） ng/ml; （ 103. 4 ±27. 2） ng/ml, （50. 2 ± 16. 6） ng/ml vs （86. 6 ± 12. 3） ng/ml, （41.1 ± 17. 1 ） ng/ml, t = 2. 83,2. 37,2.48,3.32, P 〈0. 05）. The contents of IGF-2 was significantly decreased, and IGFBP-3 was significantly increased in patients after radical operation [ （86. 6 ± 12. 3） ng/ml, （gl. 1 ± 17.1 ） ng/ml vs （ 103.2 ±26. 0）ng/ml, （45.3 ± 14. 9）ng/ml, t^1 = 3.46, t = 2. 67, P 〈 0.051- But there was no significant difference on the level of IGF-2 and IGFBP-3 before and after palliative resection （ P 〉 O. 05 ）. Conclusions The contents of serum IGF-2 and IGFBP-3 are closely related to tumor invasion, metastasis and clinical stage. Dynamic determination of the contents of serum IGF-2 and IGFBP-3 may be an important index for evaluation of invasion, metastasis, efficacy and prognosis for the patients with ovarian cancer.

关 键 词：卵巢肿瘤/代谢 胰岛素样生长因子Ⅱ/代谢 胰岛素样生长因子结合蛋白质3/代谢 手术期间 

分 类 号：R737.31[医药卫生—肿瘤]