抗着丝点抗体阳性的原发性胆汁性肝硬化患者临床分析  

Clinical analysis of positive anticentromere antibody in 46 patients with primary biliary cirrhosis

作　　者：张文忠[1] 姚萍[2] 

机构地区：[1]郑州市第六人民医院重症医学科,450015 [2]新疆医科大学第一附属医院消化科,乌鲁木齐市830054

出　　处：《中华实用诊断与治疗杂志》2011年第5期451-453,共3页Journal of Chinese Practical Diagnosis and Therapy

摘　　要：目的:探讨原发性胆汁性肝硬化(pri mary biliary cirrhosis,PBC)患者抗着丝点抗体(anticentromere antibody,ACA)与临床表现间的关系。方法:156例PBC患者,分为ACA阳性组46例,ACA阴性组110例,比较2组临床表现,肝功能及免疫学指标。结果:ACA阳性组患者乏力、黄疸发生率低于ACA阴性组(P<0.05)。2组肝功能各指标比较差异无统计学意义(P>0.05)。ACA阳性组Ig M水平和CD4+水平较ACA阴性组高(P<0.05)。结论:ACA阳性PBC患者临床表现隐匿,易漏诊。Objective To investigate the relationship between anticentromere antibody and the clinical characteristics in patients with primary biliary cirrhosis.Methods In 156 cases of primary biliary cirrhosis,anticentromere antibody was positive in 46 patients and negative in 110 patients.The clinical manifestations,the hepatic function and immunological parameters were compared between two groups.Results The incidences of fatigue and icterus in positive anticentromere antibody group were lower than those in negative anticentromere antibody group.There were no significant differences in hepatic function indexes between two groups（P0.05）.CD4＋ and IgM were higher in positive anticentromere antibody group than those in negative anticentromere antibody group,which showed significant differences（P0.05）.Conclusion The symptoms are inconspicuous in the positive anticentromere antibody patients with primary biliary cirrhosis,which leads to clinical missed diagnosis.

关 键 词：肝硬化 胆汁性 抗着丝点抗体 

分 类 号：R575.2[医药卫生—消化系统]