首发抑郁症患者大脑灰质密度基于体素的形态测量学分析  

Voxel-based morphometry on grey matter concentration of the brain in first-episode,antipsychotic-naive major depressive disorder

作　　者：张江华[1] 肖晶[1] 朱雪玲[1] 王湘[1] 姚树桥[1] 

机构地区：[1]中南大学湘雅二医院医学心理研究中心,长沙410011

出　　处：《中南大学学报（医学版）》2011年第4期307-311,共5页Journal of Central South University ：Medical Science

基　　金：国家自然科学基金(30670709;30700236)~~

摘　　要：目的:运用基于体素的形态测量学分析方法对首发抑郁症患者的全脑灰质密度特征进行研究。方法:38例首发抑郁症患者和42例正常对照接受磁共振(MR I)检查,并应用基于体素的形态测量学方法分析其全脑灰质密度的特征。结果:首发抑郁症患者右侧额中回、右侧额上回、左侧额下回以及左侧额上回的灰质密度明显低于正常对照组(P<0.001),而右侧楔前叶、左侧中央前回以及右侧前扣带回的灰质密度明显高于正常对照组(P<0.001)。结论:首发抑郁症患者的灰质密度存在结构异常,这可能是个体发生抑郁症的病理基础。Objective To examine the structural differences in regional gray matter density between a sample of major depressive disorder （MDD） and healthy controls, using the magnetic resonance imaging （MRI） to find the base of pathophysiologic mechanism in depression development. Methods A total of 38 MDD patients and 42 healthy subjects enrolled in the MRI scans. Voxel- based morphometry was used to test the difference in gray matter between the 2 groups. Results The MDD group showed significantly lower gray density than the healthy control group in the right middle frontal gyrus, right superior frontal gyrus, left inferior frontal gyrus and left superior frontal gyrus. However, the healthy control group showed significantly lower gray density than the MDD group in the right precuneus, left anterior central gyrus and right anterior cingutate. Conclusion Structural brain abnormalities in MDD patients may be the pathological bases for MDD development.

关 键 词：抑郁症 磁共振 灰质 形态测量学 

分 类 号：R749.4[医药卫生—神经病学与精神病学]